Also called: Malignant mesothelioma
The tissue that lines your lungs, stomach, heart and other organs is called mesothelium. Mesothelioma is cancer of that tissue. It is a rare but serious type of cancer. It usually starts in the lungs, but can also start in the abdomen or other organs. Most people who develop mesothelioma have worked on jobs where they inhaled asbestos particles. It can take a long time - 30 to 50 years - between being around asbestos and getting the disease. Treatment includes surgery, radiation, chemotherapy or all three.
General Information About Malignant Mesothelioma
Key Points for This Section
Malignant mesothelioma is a disease in which malignant (cancer) cells form in the lining of the chest or abdomen.
Being exposed to asbestos can affect the risk of developing malignant mesothelioma.
Possible signs of malignant mesothelioma include shortness of breath and pain under the rib cage.
Tests that examine the inside of the chest and abdomen are used to detect (find) and diagnose malignant mesothelioma.
Certain factors affect prognosis (chance of recovery) and treatment options.
Malignant mesothelioma is a disease in which malignant (cancer) cells form in the lining of the chest or abdomen.
Malignant mesothelioma is a disease in which malignant (cancer) cells are found in the pleura (the thin layer of tissue that lines the chest cavity and covers the lungs) or the peritoneum (the thin layer of tissue that lines the abdomen and covers most of the organs in the abdomen). This summary is about malignant mesothelioma of the pleura.
Sunday, June 28, 2009
Mesothelioma Diagnosis
Diagnosing mesothelioma can indeed by a tricky process. Because the symptoms are similar to those of so many other common diseases, this aggressive form of cancer can often be mistaken for something else. An accurate diagnosis largely depends on the patient providing a complete history - both medical and occupational. This may indicate any past exposure to asbestos which may have caused the disease.
Often, if the patient was exposed for just a short period of time many years ago, he/she views it as unnecessary to mention. The fact remains that ever brief exposure to asbestos may cause the disease, so it's always important to mention any situations which may have put the patient at risk.
What's the First Step?
Usually, a potential mesothelioma victim will visit their family doctor or general practitioner with complaints about a number of ailments, which often include chest pain, shortness of breath, and coughing. These are the most prevalent signs of the disease and usually the ones that appear first and that are most bothersome.
After the doctor takes a detailed history of the patient - even if meso is not yet suspected - he/she will most likely order a diagnostic test or two to further investigate the cause of the problems.
Often, the first test ordered is a traditional x-ray, which can identify pleural effusion (fluid in the lungs) or the presence of a tumor or pleural plaques or calcification. This typically indicates pleural mesothelioma.
What Comes Next?
If the x-ray shows suspicious spots or fluid retention, the doctor will probably decide to order a more sophisticated test that can help him get a better look at the affected organs. These tests might include:Computed Tomography (CT) Scans
The CT scan will provide your doctor with a more detailed picture of areas in question. While conventional x-rays focus beams of radiation towards one part of the body, the CT scan machine consists of an x-ray-generating device that rotates around the entire body. The device, which is connected to a high-tech computer, provides cross-section images (or "slices") of the inside of the body.
No preparation is necessary for a CT scan, which will be performed at either a hospital or an outpatient facility. These scans are painless and require no anesthesia. You'll simply lie on a table, which may be raised, lowered, or tilted in order for the technician to get the most accurate pictures possible. You will be provided with a pillow for your head and technicians will be sure that you are as comfortable as possible during the procedure.Magnetic Resonance Imaging (MRI)
Even more accurate than the CT scan is the MRI, a diagnostic tool that uses a magnetic field and radio waves to create cross-sectional images of the head or body. This test has proven especially successful in detecting tumors in or around the lungs, which makes it especially useful for diagnosing mesothelioma. It provides extremely clear pictures and is often the most successful of all the imaging processes in diagnosing the disease.
No preparation is needed for the MRI unless your doctor recommends that the test be done using a contrast dye. If so, you'll need to drink the harmless dye prior to the test being administered. Patients will simply lie on the table that moves through the MRI machine, which directs radio waves towards the body. Clicking and other noises may occur during the procedure but patients should be assured that they're harmless and are no indication of a problem. Most MRIs last from 30 to 90 minutes and many people fall asleep during the test. If you have a fear of closed-in spaces, some hospitals and other facilities offer open MRIs or you will be offered a sedative before the test.
The Final Step to Diagnosis
Such sophisticated imaging procedures as MRIs and CT scans usually offer a fairly clear diagnosis, but doctors almost always recommend one more test before coming to a definitive conclusion about any type of cancer. That test is known as a biopsy.
A biopsy, derived from the Greek word meaning "view of the living", involves removing a sample of fluid or tissue from the affected area and sending it to a pathologist for examination. The biopsy is done by inserting a thin needle into the area in question.
With potential mesothelioma patients, the first biopsy usually performed is one which removes fluid from around the lungs. Other doctors, however, might prefer to proceed directly to the tissue biopsy, deeming the fluid biopsy inconclusive. Still, other physicians may opt for a laparoscopy or thoracoscopy, which involves making a small incision and using a tiny camera to look at the affected area. A tissue sample can be taken during this procedure. These procedures will probably involve a local anesthetic.
Most recently, however, mesothelioma specialists have concluded that the open lung biopsy is the most reliable in making an accurate diagnosis. Akin to surgery and done under general anesthesia, an incision will be made and a small piece of lung tissue removed. The tissue will then be sent to a pathologist for examination and the doctor will receive the results at a later date. The surgeon may leave a chest tube in place for a few days to prevent the lung from collapsing.
Receiving the Diagnosis
In most cases, it will take several days or longer to receive the results of many of these tests. While it may be difficult to be patient during the waiting period, patients should be assured that doctors are offering the best tools available for an accurate diagnosis and will deliver the diagnosis as soon as possible. A proper diagnosis will help your doctor to determine the best mesothelioma treatment available.
Often, if the patient was exposed for just a short period of time many years ago, he/she views it as unnecessary to mention. The fact remains that ever brief exposure to asbestos may cause the disease, so it's always important to mention any situations which may have put the patient at risk.
What's the First Step?
Usually, a potential mesothelioma victim will visit their family doctor or general practitioner with complaints about a number of ailments, which often include chest pain, shortness of breath, and coughing. These are the most prevalent signs of the disease and usually the ones that appear first and that are most bothersome.
After the doctor takes a detailed history of the patient - even if meso is not yet suspected - he/she will most likely order a diagnostic test or two to further investigate the cause of the problems.
Often, the first test ordered is a traditional x-ray, which can identify pleural effusion (fluid in the lungs) or the presence of a tumor or pleural plaques or calcification. This typically indicates pleural mesothelioma.
What Comes Next?
If the x-ray shows suspicious spots or fluid retention, the doctor will probably decide to order a more sophisticated test that can help him get a better look at the affected organs. These tests might include:Computed Tomography (CT) Scans
The CT scan will provide your doctor with a more detailed picture of areas in question. While conventional x-rays focus beams of radiation towards one part of the body, the CT scan machine consists of an x-ray-generating device that rotates around the entire body. The device, which is connected to a high-tech computer, provides cross-section images (or "slices") of the inside of the body.
No preparation is necessary for a CT scan, which will be performed at either a hospital or an outpatient facility. These scans are painless and require no anesthesia. You'll simply lie on a table, which may be raised, lowered, or tilted in order for the technician to get the most accurate pictures possible. You will be provided with a pillow for your head and technicians will be sure that you are as comfortable as possible during the procedure.Magnetic Resonance Imaging (MRI)
Even more accurate than the CT scan is the MRI, a diagnostic tool that uses a magnetic field and radio waves to create cross-sectional images of the head or body. This test has proven especially successful in detecting tumors in or around the lungs, which makes it especially useful for diagnosing mesothelioma. It provides extremely clear pictures and is often the most successful of all the imaging processes in diagnosing the disease.
No preparation is needed for the MRI unless your doctor recommends that the test be done using a contrast dye. If so, you'll need to drink the harmless dye prior to the test being administered. Patients will simply lie on the table that moves through the MRI machine, which directs radio waves towards the body. Clicking and other noises may occur during the procedure but patients should be assured that they're harmless and are no indication of a problem. Most MRIs last from 30 to 90 minutes and many people fall asleep during the test. If you have a fear of closed-in spaces, some hospitals and other facilities offer open MRIs or you will be offered a sedative before the test.
The Final Step to Diagnosis
Such sophisticated imaging procedures as MRIs and CT scans usually offer a fairly clear diagnosis, but doctors almost always recommend one more test before coming to a definitive conclusion about any type of cancer. That test is known as a biopsy.
A biopsy, derived from the Greek word meaning "view of the living", involves removing a sample of fluid or tissue from the affected area and sending it to a pathologist for examination. The biopsy is done by inserting a thin needle into the area in question.
With potential mesothelioma patients, the first biopsy usually performed is one which removes fluid from around the lungs. Other doctors, however, might prefer to proceed directly to the tissue biopsy, deeming the fluid biopsy inconclusive. Still, other physicians may opt for a laparoscopy or thoracoscopy, which involves making a small incision and using a tiny camera to look at the affected area. A tissue sample can be taken during this procedure. These procedures will probably involve a local anesthetic.
Most recently, however, mesothelioma specialists have concluded that the open lung biopsy is the most reliable in making an accurate diagnosis. Akin to surgery and done under general anesthesia, an incision will be made and a small piece of lung tissue removed. The tissue will then be sent to a pathologist for examination and the doctor will receive the results at a later date. The surgeon may leave a chest tube in place for a few days to prevent the lung from collapsing.
Receiving the Diagnosis
In most cases, it will take several days or longer to receive the results of many of these tests. While it may be difficult to be patient during the waiting period, patients should be assured that doctors are offering the best tools available for an accurate diagnosis and will deliver the diagnosis as soon as possible. A proper diagnosis will help your doctor to determine the best mesothelioma treatment available.
Recognizing Symptoms
Just like any other disease, the symptoms of mesothelioma vary from case to case and with the severity of the illness. The type of mesothelioma - whether pleural, peritoneal, or pericardial - also determines what the symptoms might be. Often times, the general overall health of the individual, as well as his/her age, may also play a role in how the patient is affected by the disease and which symptoms are most bothersome.
One of the most difficult problems with diagnosing mesothelioma and connecting the symptoms with the disease is the fact that so many of the symptoms - both individually and in tandem - can easily be mistaken for other more common diseases like flu, pneumonia, bronchitis, heart disease, and others.
A doctor well versed in mesothelioma treatment will take time to investigate a patient's history and hopefully connect past exposure to asbestos with the symptoms. Patients, however, can do their part as well. Anyone that was ever exposed to asbestos, even if it was decades ago, should inform their doctor of the exposure. That information will not only aid the doctor in diagnosis but will also help eliminate the need for many costly and uncomfortable tests that may be ordered while fishing for a diagnosis.
Tests are being developed that will help diagnose mesothelioma at an earlier stage, even before the most common symptoms appear. It is hoped that these tests will aid in treating the disease before it reaches its most advanced stages.
The Symptoms
As was stated previously, symptoms of mesothelioma can vary, but the most common general symptoms are:
Shortness of breath or difficulty breathing
Coughing
Pain in chest or abdomen
Fluid in the chest, lungs, or abdomen
Weight loss
Loss of appetite
Inability to sleep
Husky voice
Difficulty swallowing
It is the first two symptoms that generally bring a patient to the doctor's office. Both difficulty breathing and persistent coughing are caused by the lung's inability to expand properly due to tumors in the pleural region. The growing tumors cause the pleura, pericardium, or peritoneum to expand, thus allow fluid to enter. That generally causes pain - acute to severe - in the affected regions, such as the chest or abdomen. Breathing difficulties also make it hard to sleep and often result in loss of appetite and, eventually, weight loss.
Depending on the type of mesothelioma diagnosed - pleural, pericardial, or peritoneal - symptoms might vary from the above, which pertain mostly to pleural mesothelioma, the most common form of the disease.
Common symptoms of peritoneal mesothelioma might include:
Abdominal pain, acute to severe
Swelling of the abdominal region due to fluid accumulation
Breathing difficulties
Loss of appetite resulting in weight loss
Bowel obstruction
Nausea
Vomiting
Weakness
Fever
Anemia
Common symptoms of pericardial mesothelioma might include:
Chest pain, ranging from uncomfortable to severe
Shortness of breath
Heart palpitations
Persistent coughing
Extreme fatigue after minimal activity or exertion
Because the three types of the disease are similar but centered in different parts of the body, the patient is likely to have symptoms that overlap. For example, nearly all meso patients suffer from shortness of breath and fatigue, but the pain may be more apparent in the abdominal/stomach area for peritoneal patients and in the chest for those with pleural or pericardial mesothelioma.
Ascertaining a Diagnosis
If a doctor recognizes symptoms as indicative of mesothelioma or another asbestos-related disease, such as asbestosis, the patient will be asked to undergo several tests. Most doctors begin by ordering a conventional x-ray in order to get a closer look at the chest or abdomen. What appears on this x-ray will be the first indication of whether or not the doctor should continue pursuing his suspected diagnosis and order additional tests.
If mesothelioma is still suspected after the x-ray, an MRI or CT scan will most likely be in order. These sophisticated imaging processes allow an even closer look at organs such as the lungs or abdomen. A blood test may be ordered as well because such tests can measure the levels of specific proteins, which might aid in the diagnosis.
However, because other more common diseases, such as benign asbestos-related pleural disease, can have very similar appearances on imaging studies, a tissue biopsy is usually recommended and is often the final test that leads to an accurate diagnosis.
One of the most difficult problems with diagnosing mesothelioma and connecting the symptoms with the disease is the fact that so many of the symptoms - both individually and in tandem - can easily be mistaken for other more common diseases like flu, pneumonia, bronchitis, heart disease, and others.
A doctor well versed in mesothelioma treatment will take time to investigate a patient's history and hopefully connect past exposure to asbestos with the symptoms. Patients, however, can do their part as well. Anyone that was ever exposed to asbestos, even if it was decades ago, should inform their doctor of the exposure. That information will not only aid the doctor in diagnosis but will also help eliminate the need for many costly and uncomfortable tests that may be ordered while fishing for a diagnosis.
Tests are being developed that will help diagnose mesothelioma at an earlier stage, even before the most common symptoms appear. It is hoped that these tests will aid in treating the disease before it reaches its most advanced stages.
The Symptoms
As was stated previously, symptoms of mesothelioma can vary, but the most common general symptoms are:
Shortness of breath or difficulty breathing
Coughing
Pain in chest or abdomen
Fluid in the chest, lungs, or abdomen
Weight loss
Loss of appetite
Inability to sleep
Husky voice
Difficulty swallowing
It is the first two symptoms that generally bring a patient to the doctor's office. Both difficulty breathing and persistent coughing are caused by the lung's inability to expand properly due to tumors in the pleural region. The growing tumors cause the pleura, pericardium, or peritoneum to expand, thus allow fluid to enter. That generally causes pain - acute to severe - in the affected regions, such as the chest or abdomen. Breathing difficulties also make it hard to sleep and often result in loss of appetite and, eventually, weight loss.
Depending on the type of mesothelioma diagnosed - pleural, pericardial, or peritoneal - symptoms might vary from the above, which pertain mostly to pleural mesothelioma, the most common form of the disease.
Common symptoms of peritoneal mesothelioma might include:
Abdominal pain, acute to severe
Swelling of the abdominal region due to fluid accumulation
Breathing difficulties
Loss of appetite resulting in weight loss
Bowel obstruction
Nausea
Vomiting
Weakness
Fever
Anemia
Common symptoms of pericardial mesothelioma might include:
Chest pain, ranging from uncomfortable to severe
Shortness of breath
Heart palpitations
Persistent coughing
Extreme fatigue after minimal activity or exertion
Because the three types of the disease are similar but centered in different parts of the body, the patient is likely to have symptoms that overlap. For example, nearly all meso patients suffer from shortness of breath and fatigue, but the pain may be more apparent in the abdominal/stomach area for peritoneal patients and in the chest for those with pleural or pericardial mesothelioma.
Ascertaining a Diagnosis
If a doctor recognizes symptoms as indicative of mesothelioma or another asbestos-related disease, such as asbestosis, the patient will be asked to undergo several tests. Most doctors begin by ordering a conventional x-ray in order to get a closer look at the chest or abdomen. What appears on this x-ray will be the first indication of whether or not the doctor should continue pursuing his suspected diagnosis and order additional tests.
If mesothelioma is still suspected after the x-ray, an MRI or CT scan will most likely be in order. These sophisticated imaging processes allow an even closer look at organs such as the lungs or abdomen. A blood test may be ordered as well because such tests can measure the levels of specific proteins, which might aid in the diagnosis.
However, because other more common diseases, such as benign asbestos-related pleural disease, can have very similar appearances on imaging studies, a tissue biopsy is usually recommended and is often the final test that leads to an accurate diagnosis.
Recognizing Symptoms
Just like any other disease, the symptoms of mesothelioma vary from case to case and with the severity of the illness. The type of mesothelioma - whether pleural, peritoneal, or pericardial - also determines what the symptoms might be. Often times, the general overall health of the individual, as well as his/her age, may also play a role in how the patient is affected by the disease and which symptoms are most bothersome.
One of the most difficult problems with diagnosing mesothelioma and connecting the symptoms with the disease is the fact that so many of the symptoms - both individually and in tandem - can easily be mistaken for other more common diseases like flu, pneumonia, bronchitis, heart disease, and others.
A doctor well versed in mesothelioma treatment will take time to investigate a patient's history and hopefully connect past exposure to asbestos with the symptoms. Patients, however, can do their part as well. Anyone that was ever exposed to asbestos, even if it was decades ago, should inform their doctor of the exposure. That information will not only aid the doctor in diagnosis but will also help eliminate the need for many costly and uncomfortable tests that may be ordered while fishing for a diagnosis.
Tests are being developed that will help diagnose mesothelioma at an earlier stage, even before the most common symptoms appear. It is hoped that these tests will aid in treating the disease before it reaches its most advanced stages.
The Symptoms
As was stated previously, symptoms of mesothelioma can vary, but the most common general symptoms are:
Shortness of breath or difficulty breathing
Coughing
Pain in chest or abdomen
Fluid in the chest, lungs, or abdomen
Weight loss
Loss of appetite
Inability to sleep
Husky voice
Difficulty swallowing
It is the first two symptoms that generally bring a patient to the doctor's office. Both difficulty breathing and persistent coughing are caused by the lung's inability to expand properly due to tumors in the pleural region. The growing tumors cause the pleura, pericardium, or peritoneum to expand, thus allow fluid to enter. That generally causes pain - acute to severe - in the affected regions, such as the chest or abdomen. Breathing difficulties also make it hard to sleep and often result in loss of appetite and, eventually, weight loss.
Depending on the type of mesothelioma diagnosed - pleural, pericardial, or peritoneal - symptoms might vary from the above, which pertain mostly to pleural mesothelioma, the most common form of the disease.
If a doctor recognizes symptoms as indicative of mesothelioma or another asbestos-related disease, such as asbestosis, the patient will be asked to undergo several tests. Most doctors begin by ordering a conventional x-ray in order to get a closer look at the chest or abdomen. What appears on this x-ray will be the first indication of whether or not the doctor should continue pursuing his suspected diagnosis and order additional tests.
If mesothelioma is still suspected after the x-ray, an MRI or CT scan will most likely be in order. These sophisticated imaging processes allow an even closer look at organs such as the lungs or abdomen. A blood test may be ordered as well because such tests can measure the levels of specific proteins, which might aid in the diagnosis.
However, because other more common diseases, such as benign asbestos-related pleural disease, can have very similar appearances on imaging studies, a tissue biopsy is usually recommended and is often the final test that leads to an accurate diagnosis.
One of the most difficult problems with diagnosing mesothelioma and connecting the symptoms with the disease is the fact that so many of the symptoms - both individually and in tandem - can easily be mistaken for other more common diseases like flu, pneumonia, bronchitis, heart disease, and others.
A doctor well versed in mesothelioma treatment will take time to investigate a patient's history and hopefully connect past exposure to asbestos with the symptoms. Patients, however, can do their part as well. Anyone that was ever exposed to asbestos, even if it was decades ago, should inform their doctor of the exposure. That information will not only aid the doctor in diagnosis but will also help eliminate the need for many costly and uncomfortable tests that may be ordered while fishing for a diagnosis.
Tests are being developed that will help diagnose mesothelioma at an earlier stage, even before the most common symptoms appear. It is hoped that these tests will aid in treating the disease before it reaches its most advanced stages.
The Symptoms
As was stated previously, symptoms of mesothelioma can vary, but the most common general symptoms are:
Shortness of breath or difficulty breathing
Coughing
Pain in chest or abdomen
Fluid in the chest, lungs, or abdomen
Weight loss
Loss of appetite
Inability to sleep
Husky voice
Difficulty swallowing
It is the first two symptoms that generally bring a patient to the doctor's office. Both difficulty breathing and persistent coughing are caused by the lung's inability to expand properly due to tumors in the pleural region. The growing tumors cause the pleura, pericardium, or peritoneum to expand, thus allow fluid to enter. That generally causes pain - acute to severe - in the affected regions, such as the chest or abdomen. Breathing difficulties also make it hard to sleep and often result in loss of appetite and, eventually, weight loss.
Depending on the type of mesothelioma diagnosed - pleural, pericardial, or peritoneal - symptoms might vary from the above, which pertain mostly to pleural mesothelioma, the most common form of the disease.
- Common symptoms of peritoneal mesothelioma might include:
- Abdominal pain, acute to severe
- Swelling of the abdominal region due to fluid accumulation
- Breathing difficulties
- Loss of appetite resulting in weight loss
- Bowel obstruction
- Nausea
- Vomiting
- Weakness
- Fever
- Anemia
- Common symptoms of pericardial mesothelioma might include:
- Chest pain, ranging from uncomfortable to severe
- Shortness of breath
- Heart palpitations
- Persistent coughing
- Extreme fatigue after minimal activity or exertion
- Because the three types of the disease are similar but centered in different parts of the body, the patient is likely to have symptoms that overlap. For example, nearly all meso patients suffer from shortness of breath and fatigue, but the pain may be more apparent in the abdominal/stomach area for peritoneal patients and in the chest for those with pleural or pericardial mesothelioma.
If a doctor recognizes symptoms as indicative of mesothelioma or another asbestos-related disease, such as asbestosis, the patient will be asked to undergo several tests. Most doctors begin by ordering a conventional x-ray in order to get a closer look at the chest or abdomen. What appears on this x-ray will be the first indication of whether or not the doctor should continue pursuing his suspected diagnosis and order additional tests.
If mesothelioma is still suspected after the x-ray, an MRI or CT scan will most likely be in order. These sophisticated imaging processes allow an even closer look at organs such as the lungs or abdomen. A blood test may be ordered as well because such tests can measure the levels of specific proteins, which might aid in the diagnosis.
However, because other more common diseases, such as benign asbestos-related pleural disease, can have very similar appearances on imaging studies, a tissue biopsy is usually recommended and is often the final test that leads to an accurate diagnosis.
What is Mesothelioma?
Throughout the past decade, the term "mesothelioma" has become more and more recognizable. Once an obscure disease that meant little to the general public, mention of this disease now conjures up thoughts and pictures of factories and mines strewn with asbestos and the unfortunate workers who were employed in those dangerous places.
Thanks to concerned medical professionals, researchers, and watchdog organizations, we're learning more and more about mesothelioma and how it affects the lives of those who are afflicted. However, there's still far to go as both better treatments and a cure for the disease are sought.
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About the Disease
Simply put, mesothelioma which is commonly referred to as asbestos cancer, is an aggressive cancer caused primarily by the inhalation of dangerous asbestos fibers. The disease attacks the mesothelium, a protective, two-layered membrane that covers the internal organs of the body including the lungs, heart and abdominal organs. Between these layers, the cells produce fluid, which allows easy movement of the heart and lungs within the chest cavity. The layer that covers the lungs is called the pleura, and the layer that covers the heart is called the pericardium. The peritoneum lines the abdominal cavity. Mesothelium also lines the male and female reproductive organs. Mesothelioma can affect any of these cells, but is usually seen in the pleural or peritoneal mesothelium. The most commonly diagnosed form of this cancer is pleural mesothelioma.
Mesothelioma takes anywhere from 20 to 50 years to develop, which is why older individuals are usually the victims. However, recent cases involving September 11th World Trade Center first responders and clean-up crews show that high concentrations of asbestos can cause the disease to develop much more rapidly. A few WTC workers have already died of the disease.
Effects of the Disease
The invasion of the mesothelium by cancer cells makes it very difficult for the patient to breathe, resulting in the need for oxygen, especially as the disease progresses. Those with the pleural form of mesothelioma may also suffer from pleural effusions. These effusions prevent the smooth movement of the lungs and other organs in the chest. Peritoneal mesothelioma also affects the stomach area and abdominal cavity, causing nausea, vomiting, or loss of appetite, which can result in dangerous weight loss. In addition to breathing difficulties and loss of appetite, mesothelioma victims also complain of excessive coughing, sleeping difficulties, persistent chest pain, fever, and pain in the lower back.
Mesothelioma, in general, is a very painful disease and because it is usually not diagnosed until it's in an advanced stage. For this reason, the symptoms are typically quite serious. Late diagnosis also means that the cancer is more likely to have metastasized, or spread, making successful mesothelioma treatment even more difficult.
Who Gets Mesothelioma?
Statistics show that, because of their work history, the disease most often affects men between the ages of 50 and 70 who were employed in an asbestos-laden environment before asbestos warnings and bans were in place in the 1970s. Though women still have a much lower frequency of the disease, cases of second-hand exposure to asbestos has prompted more diagnoses among women, especially those whose male family members worked with asbestos. The occupations most associated with mesothelioma are shipyard workers, electricians, plumbers, construction industry workers, pipefitters, boilermakers, and anyone subject to heavy exposure to dangerous asbestos and airborne asbestos fibers.
An abundance of cases have also demonstrated that mesothelioma can develop among people who lived in communities where asbestos factories or mines were located. In some instances, entire towns have been adversely affected by the presence of asbestos fibers in the air. For example, in Libby, Montana - site of a former vermiculite asbestos mine - hundreds have already died of mesothelioma.
Though still significantly rarer than other cancers, an estimated 2,000 to 3,000 new cases of mesothelioma are diagnosed each year in the United States. Other countries, notably the United Kingdom and Australia, report a much higher incidence of the disease. Nevertheless, the United States - like many other countries - has seen an increase in asbestos-caused cancer as men who worked in U.S. shipyards in the 1940s and 1950s, at the height of production, are now being diagnosed with mesothelioma.
Dealing with Mesothelioma
Mesothelioma is most often diagnosed in its late stages, and such a diagnosis is devastating to the individual and his/her family. Though research into the disease has been ongoing, there is currently no cure for mesothelioma. Some patients may be candidates for surgery to remove tumors or even an entire lung, but most are better treated with radiation or chemotherapy. More often than not, these treatments are palliative, serving to lessen the severity of the symptoms of the disease rather than offering a cure.
Medical professionals and research scientists, however, are constantly exploring new ways to combat the disease. For example, doctors know that some combinations of chemotherapy drugs work better than others and tests developed to ascertain earlier diagnosis of the disease or to monitor those most at risk have arrived on the scene.
Who's to Blame?
The reason someone develops mesothelioma is usually the lack of proper protection offered to those who worked with asbestos. Though the dangerous properties of asbestos and asbestos products have been evident for decades, many employers neglected to protect their workers from inhaling asbestos while on the job. It wasn't until public awareness of the dangers of the material were revealed in the 1970s that many employers began offering protective clothing such as respirators, gloves, aprons, and other such items to those working with asbestos on a daily basis.
Due to the negligence of employers, many companies who manufacture asbestos or products that contain asbestos have been subject to literally thousands of lawsuits filed by those who've been harmed by the material. Many of those lawsuits have come from individuals suffering from mesothelioma.
Thanks to concerned medical professionals, researchers, and watchdog organizations, we're learning more and more about mesothelioma and how it affects the lives of those who are afflicted. However, there's still far to go as both better treatments and a cure for the disease are sought.
-->
About the Disease
Simply put, mesothelioma which is commonly referred to as asbestos cancer, is an aggressive cancer caused primarily by the inhalation of dangerous asbestos fibers. The disease attacks the mesothelium, a protective, two-layered membrane that covers the internal organs of the body including the lungs, heart and abdominal organs. Between these layers, the cells produce fluid, which allows easy movement of the heart and lungs within the chest cavity. The layer that covers the lungs is called the pleura, and the layer that covers the heart is called the pericardium. The peritoneum lines the abdominal cavity. Mesothelium also lines the male and female reproductive organs. Mesothelioma can affect any of these cells, but is usually seen in the pleural or peritoneal mesothelium. The most commonly diagnosed form of this cancer is pleural mesothelioma.
Mesothelioma takes anywhere from 20 to 50 years to develop, which is why older individuals are usually the victims. However, recent cases involving September 11th World Trade Center first responders and clean-up crews show that high concentrations of asbestos can cause the disease to develop much more rapidly. A few WTC workers have already died of the disease.
Effects of the Disease
The invasion of the mesothelium by cancer cells makes it very difficult for the patient to breathe, resulting in the need for oxygen, especially as the disease progresses. Those with the pleural form of mesothelioma may also suffer from pleural effusions. These effusions prevent the smooth movement of the lungs and other organs in the chest. Peritoneal mesothelioma also affects the stomach area and abdominal cavity, causing nausea, vomiting, or loss of appetite, which can result in dangerous weight loss. In addition to breathing difficulties and loss of appetite, mesothelioma victims also complain of excessive coughing, sleeping difficulties, persistent chest pain, fever, and pain in the lower back.
Mesothelioma, in general, is a very painful disease and because it is usually not diagnosed until it's in an advanced stage. For this reason, the symptoms are typically quite serious. Late diagnosis also means that the cancer is more likely to have metastasized, or spread, making successful mesothelioma treatment even more difficult.
Who Gets Mesothelioma?
Statistics show that, because of their work history, the disease most often affects men between the ages of 50 and 70 who were employed in an asbestos-laden environment before asbestos warnings and bans were in place in the 1970s. Though women still have a much lower frequency of the disease, cases of second-hand exposure to asbestos has prompted more diagnoses among women, especially those whose male family members worked with asbestos. The occupations most associated with mesothelioma are shipyard workers, electricians, plumbers, construction industry workers, pipefitters, boilermakers, and anyone subject to heavy exposure to dangerous asbestos and airborne asbestos fibers.
An abundance of cases have also demonstrated that mesothelioma can develop among people who lived in communities where asbestos factories or mines were located. In some instances, entire towns have been adversely affected by the presence of asbestos fibers in the air. For example, in Libby, Montana - site of a former vermiculite asbestos mine - hundreds have already died of mesothelioma.
Though still significantly rarer than other cancers, an estimated 2,000 to 3,000 new cases of mesothelioma are diagnosed each year in the United States. Other countries, notably the United Kingdom and Australia, report a much higher incidence of the disease. Nevertheless, the United States - like many other countries - has seen an increase in asbestos-caused cancer as men who worked in U.S. shipyards in the 1940s and 1950s, at the height of production, are now being diagnosed with mesothelioma.
Dealing with Mesothelioma
Mesothelioma is most often diagnosed in its late stages, and such a diagnosis is devastating to the individual and his/her family. Though research into the disease has been ongoing, there is currently no cure for mesothelioma. Some patients may be candidates for surgery to remove tumors or even an entire lung, but most are better treated with radiation or chemotherapy. More often than not, these treatments are palliative, serving to lessen the severity of the symptoms of the disease rather than offering a cure.
Medical professionals and research scientists, however, are constantly exploring new ways to combat the disease. For example, doctors know that some combinations of chemotherapy drugs work better than others and tests developed to ascertain earlier diagnosis of the disease or to monitor those most at risk have arrived on the scene.
Who's to Blame?
The reason someone develops mesothelioma is usually the lack of proper protection offered to those who worked with asbestos. Though the dangerous properties of asbestos and asbestos products have been evident for decades, many employers neglected to protect their workers from inhaling asbestos while on the job. It wasn't until public awareness of the dangers of the material were revealed in the 1970s that many employers began offering protective clothing such as respirators, gloves, aprons, and other such items to those working with asbestos on a daily basis.
Due to the negligence of employers, many companies who manufacture asbestos or products that contain asbestos have been subject to literally thousands of lawsuits filed by those who've been harmed by the material. Many of those lawsuits have come from individuals suffering from mesothelioma.
Mesothelioma
Mesothelioma is a form of cancer that is almost always caused by exposure to asbestos. In this disease, malignant cells develop in the mesothelium, a protective lining that covers most of the body's internal organs. Its most common site is the pleura (outer lining of the lungs and internal chest wall), but it may also occur in the peritoneum (the lining of the abdominal cavity), the heart,[1] the pericardium (a sac that surrounds the heart) or tunica vaginalis.
Most people who develop mesothelioma have worked on jobs where they inhaled asbestos particles, or they have been exposed to asbestos dust and fiber in other ways. Washing the clothes of a family member who worked with asbestos can also put a person at risk for developing mesothelioma.[2] Unlike lung cancer, there is no association between mesothelioma and smoking, but smoking greatly increases risk of other asbestos-induced cancer.[3] Compensation via asbestos funds or lawsuits is an important issue in mesothelioma (see asbestos and the law).
The symptoms of mesothelioma include shortness of breath due to pleural effusion (fluid between the lung and the chest wall) or chest wall pain, and general symptoms such as weight loss. The diagnosis may be suspected with chest X-ray and CT scan, and is confirmed with a biopsy (tissue sample) and microscopic examination. A thoracoscopy (inserting a tube with a camera into the chest) can be used to take biopsies. It allows the introduction of substances such as talc to obliterate the pleural space (called pleurodesis), which prevents more fluid from accumulating and pressing on the lung. Despite treatment with chemotherapy, radiation therapy or sometimes surgery, the disease carries a poor prognosis. Research about screening tests for the early detection of mesothelioma is ongoing.
Most people who develop mesothelioma have worked on jobs where they inhaled asbestos particles, or they have been exposed to asbestos dust and fiber in other ways. Washing the clothes of a family member who worked with asbestos can also put a person at risk for developing mesothelioma.[2] Unlike lung cancer, there is no association between mesothelioma and smoking, but smoking greatly increases risk of other asbestos-induced cancer.[3] Compensation via asbestos funds or lawsuits is an important issue in mesothelioma (see asbestos and the law).
The symptoms of mesothelioma include shortness of breath due to pleural effusion (fluid between the lung and the chest wall) or chest wall pain, and general symptoms such as weight loss. The diagnosis may be suspected with chest X-ray and CT scan, and is confirmed with a biopsy (tissue sample) and microscopic examination. A thoracoscopy (inserting a tube with a camera into the chest) can be used to take biopsies. It allows the introduction of substances such as talc to obliterate the pleural space (called pleurodesis), which prevents more fluid from accumulating and pressing on the lung. Despite treatment with chemotherapy, radiation therapy or sometimes surgery, the disease carries a poor prognosis. Research about screening tests for the early detection of mesothelioma is ongoing.
Mesothelioma
Mesothelioma is a form of cancer that is almost always caused by exposure to asbestos. In this disease, malignant cells develop in the mesothelium, a protective lining that covers most of the body's internal organs. Its most common site is the pleura (outer lining of the lungs and internal chest wall), but it may also occur in the peritoneum (the lining of the abdominal cavity), the heart,[1] the pericardium (a sac that surrounds the heart) or tunica vaginalis.
Most people who develop mesothelioma have worked on jobs where they inhaled asbestos particles, or they have been exposed to asbestos dust and fiber in other ways. Washing the clothes of a family member who worked with asbestos can also put a person at risk for developing mesothelioma.[2] Unlike lung cancer, there is no association between mesothelioma and smoking, but smoking greatly increases risk of other asbestos-induced cancer.[3] Compensation via asbestos funds or lawsuits is an important issue in mesothelioma (see asbestos and the law).
The symptoms of mesothelioma include shortness of breath due to pleural effusion (fluid between the lung and the chest wall) or chest wall pain, and general symptoms such as weight loss. The diagnosis may be suspected with chest X-ray and CT scan, and is confirmed with a biopsy (tissue sample) and microscopic examination. A thoracoscopy (inserting a tube with a camera into the chest) can be used to take biopsies. It allows the introduction of substances such as talc to obliterate the pleural space (called pleurodesis), which prevents more fluid from accumulating and pressing on the lung. Despite treatment with chemotherapy, radiation therapy or sometimes surgery, the disease carries a poor prognosis. Research about screening tests for the early detection of mesothelioma is ongoing.
Most people who develop mesothelioma have worked on jobs where they inhaled asbestos particles, or they have been exposed to asbestos dust and fiber in other ways. Washing the clothes of a family member who worked with asbestos can also put a person at risk for developing mesothelioma.[2] Unlike lung cancer, there is no association between mesothelioma and smoking, but smoking greatly increases risk of other asbestos-induced cancer.[3] Compensation via asbestos funds or lawsuits is an important issue in mesothelioma (see asbestos and the law).
The symptoms of mesothelioma include shortness of breath due to pleural effusion (fluid between the lung and the chest wall) or chest wall pain, and general symptoms such as weight loss. The diagnosis may be suspected with chest X-ray and CT scan, and is confirmed with a biopsy (tissue sample) and microscopic examination. A thoracoscopy (inserting a tube with a camera into the chest) can be used to take biopsies. It allows the introduction of substances such as talc to obliterate the pleural space (called pleurodesis), which prevents more fluid from accumulating and pressing on the lung. Despite treatment with chemotherapy, radiation therapy or sometimes surgery, the disease carries a poor prognosis. Research about screening tests for the early detection of mesothelioma is ongoing.
Sunday, June 21, 2009
A Mesothelioma Cure
Following the backlash of asbestos-related exposures and illnesses, many people were wondering how scientific research was going to proceed. The response has been encouraging, with cancer specialists and other doctors working each day towards a cure for malignant mesothelioma. While a way to completely eliminate the cancer from the body does not presently exist, there are several successful mesothelioma treatment programs as well as clinical trials that are working towards developing a way to eliminate this unfortunate form of cancer.
Treatments for patients of malignant mesothelioma commonly fall in line with treatment of other lung and lung-related cancers. Curative treatments are those which remove the cancer from the body completely. While there are no cures for mesothelioma, any treatment could theoretically be curative, so long as it is successful in completely removing the cancer from the body. While the treatment may be curative, it is important to remember that curative treatments do not rule out the recurrence of the disease.
While curative treatments may not prevent the disease from recurring, it is important to be aware of current initiatives that are working towards a total cure for the disease. There have been instances of unique treatment programs that have prevented the recurrence of the disease for several years. Paul Krauss was diagnosed with mesothelioma in 1997 and given only a few months to live by his physician. Today, Paul Krauss is still alive and active and has dedicated himself towards spreading awareness of the disease and working with others in developing treatment programs that would be as successful as his has been.
Combination treatments, which integrate two or more different treatment options, such as surgery coupled with radiation, or surgery paired with radiation and chemotherapy have been successful in extending life expectancies. Researchers believe that when the right combination of therapies is found, prognoses will be far longer than anyone could have imagined when the disease first manifested. Technology has also afforded new possibilities to mesothelioma patients. CT (Computer Topography) scans have been able to map three-dimensional images of the body's internal organs for targeted chemotherapy or radiation therapy to be administered.
Another novel technique is being integrated with surgical resections of mesothelioma tumors. Heated chemotherapeutic agents have shown increased proficiency in the elimination of cancer cells. Side effects of chemotherapy have, in the past, prevented physicians from delivering an optimal dosage of the drug. However, a novel procedure known as intracavity heated chemotherapy treatment has integrated these two concepts into a successful program. Heated chemotherapeutic agent is administered directly to the affected area during the surgical removal, destroying any remaining cancer cells in the area and extending prognoses well beyond typical timeframs.
It is through technology and advancements such as these that cancer specialists and physicians are laying the groundwork for a cure.
Treatments for patients of malignant mesothelioma commonly fall in line with treatment of other lung and lung-related cancers. Curative treatments are those which remove the cancer from the body completely. While there are no cures for mesothelioma, any treatment could theoretically be curative, so long as it is successful in completely removing the cancer from the body. While the treatment may be curative, it is important to remember that curative treatments do not rule out the recurrence of the disease.
While curative treatments may not prevent the disease from recurring, it is important to be aware of current initiatives that are working towards a total cure for the disease. There have been instances of unique treatment programs that have prevented the recurrence of the disease for several years. Paul Krauss was diagnosed with mesothelioma in 1997 and given only a few months to live by his physician. Today, Paul Krauss is still alive and active and has dedicated himself towards spreading awareness of the disease and working with others in developing treatment programs that would be as successful as his has been.
Combination treatments, which integrate two or more different treatment options, such as surgery coupled with radiation, or surgery paired with radiation and chemotherapy have been successful in extending life expectancies. Researchers believe that when the right combination of therapies is found, prognoses will be far longer than anyone could have imagined when the disease first manifested. Technology has also afforded new possibilities to mesothelioma patients. CT (Computer Topography) scans have been able to map three-dimensional images of the body's internal organs for targeted chemotherapy or radiation therapy to be administered.
Another novel technique is being integrated with surgical resections of mesothelioma tumors. Heated chemotherapeutic agents have shown increased proficiency in the elimination of cancer cells. Side effects of chemotherapy have, in the past, prevented physicians from delivering an optimal dosage of the drug. However, a novel procedure known as intracavity heated chemotherapy treatment has integrated these two concepts into a successful program. Heated chemotherapeutic agent is administered directly to the affected area during the surgical removal, destroying any remaining cancer cells in the area and extending prognoses well beyond typical timeframs.
It is through technology and advancements such as these that cancer specialists and physicians are laying the groundwork for a cure.
Mesothelioma Treatment 1
A diagnosis of mesothelioma is always difficult, whether it is pleural mesothelioma or another variety. Because this is such an aggressive and stubborn form of cancer, patients and their families may have a difficult time addressing the issue of treatment, but because options for mesothelioma patients are steadily increasing, the discussion of treatment is quite important, even if all hope seems lost.
Each mesothelioma case is considered individually and there is no right or wrong treatment for the disease. What's best for you or your loved one will depend on a number of factors. Diagnostic tools such as x-rays, MRIs, CT scans, and biopsies will be used to determine these factors and these tests will assist the doctor and/or oncologist in determining the best treatment for the patient in question.
What are the Options?
Cancer treatment usually focuses upon destroying malignant cells and preserving healthy ones. This can be accomplished in a number of ways. At present, mesothelioma patients are faced with three major options for treatment of their disease - surgery, radiation, and chemotherapy. What course of treatment is recommended will largely depend on these issues:
* The type of mesothelioma and location of the tumor
* The size of the tumor(s)
* The degree to which the cancer has spread or metastasized
* The stage of the cancer - beginning, advanced, etc.
* The age of the patient
* The overall physical health of the patient
Setting up any type of treatment may involve seeing a variety of doctors, including an oncologist (cancer specialist), pulmonologist (lung specialist), or radiologist. Patience is sometimes necessary, but doctors will no doubt set up treatment as soon as possible after diagnosis.
Surgery
Surgery can be performed on mesothelioma patients for one of two reasons: in an attempt to cure the disease or for palliative reasons in order to keep the patient more comfortable and improve the quality of life. Unfortunately, because mesothelioma is almost always diagnosed in its late stages, curative surgery is not usually an option.
As tests are developed that may help to diagnose mesothelioma at an earlier stage, surgery may become more of an option in the future. At that point, doctors may be able to attempt to remove the cancer and some of the surrounding tissue in an attempt to stabilize the disease.
More often, however, surgery is used as a palliative measure. For example, doctors may opt for a surgery called a pleurodesis, which involves injecting talc into the lungs to prevent fluid from returning. A thoracentesis, a surgical procedure that removes fluid from the lungs by means of a thin needle, may also be recommended.
In severe cases, a pleurectomy may be recommended for palliative purposes. This involves removing the pleura - the lining of the lung - and can control fluid build-up and lessen pain and breathing difficulties.
Radiation Therapy
If a patients health is too fragile for surgery or chemotherapy, radiation is often recommended. Radiation causes the fewest side effects and is usually easier to tolerate than chemo. There are a few different forms of radiation therapy available to meso patients:
External beam radiation - the preferred type to treat mesothelioma, this type of radiation comes from a machine outside the body and is aimed toward affected areas. Usually administered 5-days-a-week for up to 5 weeks, this type of radiation is often used for palliative purposes - to lessen breathing difficulties, pain, bleeding, or difficulty swallowing - but seldom has much of an effect on the mesothelioma tumors. This type of radiation may also be used in addition to surgery.
Brachytherapy - Rarely prescribed for mesothelioma, this kind of radiation places radioactive material directly inside the lung or abdomen.
Chemotherapy
Like radiation, chemotherapy provides no cure for mesothelioma but can go a long way in providing relief from the horrendous symptoms of the disease. As researchers continue to test different combinations of chemotherapy drugs, patients continue to benefit from their findings, and someday, chemo may go a lot further in prolonging the life of a mesothelioma victim.
Chemotherapy is given in pill form or injected. In the case of mesothelioma patients, the drugs are given intrapleurally (into the chest cavity) or intraperitoneally (into the abdominal cavity). Doctors usually combine two drugs for the best result. Currently, the preferred combination is Alimta© (pemetrexed) and Cisplatin, but other drugs are used in tandem if deemed preferable for a specific patient. In some cases, patients can only tolerate a single drug so only one is used for treatment.
Other drugs are given to the patient to combat the unpleasant side effects of chemo, such as medication to relieve nausea and vomiting or vitamins to replace essential ones lost during chemotherapy.
Some patients decide that the side effects of chemotherapy are too severe and opt not to receive this treatment.
Clinical Trials
Mesothelioma Treatment
Clinical trials are the study of promising new treatments for a particular disease. These trials are constantly in need of patients who are willing to try these experimental treatments before they are approved by the FDA. Patients should speak to their doctors about current clinical trials available to them and if they might qualify to be a part of a particular study. Those opting to participate in a clinical trial should carefully weigh the pros and cons before agreeing to participate.
Alternative Therapies
Alternative therapies include potential treatment for a disease or its symptoms that are not part of the conventional treatment generally recommended for patients with the disease. These might include the use of vitamins or herbs or participation in therapies such as acupuncture, massage, or hypnosis.
Each mesothelioma case is considered individually and there is no right or wrong treatment for the disease. What's best for you or your loved one will depend on a number of factors. Diagnostic tools such as x-rays, MRIs, CT scans, and biopsies will be used to determine these factors and these tests will assist the doctor and/or oncologist in determining the best treatment for the patient in question.
What are the Options?
Cancer treatment usually focuses upon destroying malignant cells and preserving healthy ones. This can be accomplished in a number of ways. At present, mesothelioma patients are faced with three major options for treatment of their disease - surgery, radiation, and chemotherapy. What course of treatment is recommended will largely depend on these issues:
* The type of mesothelioma and location of the tumor
* The size of the tumor(s)
* The degree to which the cancer has spread or metastasized
* The stage of the cancer - beginning, advanced, etc.
* The age of the patient
* The overall physical health of the patient
Setting up any type of treatment may involve seeing a variety of doctors, including an oncologist (cancer specialist), pulmonologist (lung specialist), or radiologist. Patience is sometimes necessary, but doctors will no doubt set up treatment as soon as possible after diagnosis.
Surgery
Surgery can be performed on mesothelioma patients for one of two reasons: in an attempt to cure the disease or for palliative reasons in order to keep the patient more comfortable and improve the quality of life. Unfortunately, because mesothelioma is almost always diagnosed in its late stages, curative surgery is not usually an option.
As tests are developed that may help to diagnose mesothelioma at an earlier stage, surgery may become more of an option in the future. At that point, doctors may be able to attempt to remove the cancer and some of the surrounding tissue in an attempt to stabilize the disease.
More often, however, surgery is used as a palliative measure. For example, doctors may opt for a surgery called a pleurodesis, which involves injecting talc into the lungs to prevent fluid from returning. A thoracentesis, a surgical procedure that removes fluid from the lungs by means of a thin needle, may also be recommended.
In severe cases, a pleurectomy may be recommended for palliative purposes. This involves removing the pleura - the lining of the lung - and can control fluid build-up and lessen pain and breathing difficulties.
Radiation Therapy
If a patients health is too fragile for surgery or chemotherapy, radiation is often recommended. Radiation causes the fewest side effects and is usually easier to tolerate than chemo. There are a few different forms of radiation therapy available to meso patients:
External beam radiation - the preferred type to treat mesothelioma, this type of radiation comes from a machine outside the body and is aimed toward affected areas. Usually administered 5-days-a-week for up to 5 weeks, this type of radiation is often used for palliative purposes - to lessen breathing difficulties, pain, bleeding, or difficulty swallowing - but seldom has much of an effect on the mesothelioma tumors. This type of radiation may also be used in addition to surgery.
Brachytherapy - Rarely prescribed for mesothelioma, this kind of radiation places radioactive material directly inside the lung or abdomen.
Chemotherapy
Like radiation, chemotherapy provides no cure for mesothelioma but can go a long way in providing relief from the horrendous symptoms of the disease. As researchers continue to test different combinations of chemotherapy drugs, patients continue to benefit from their findings, and someday, chemo may go a lot further in prolonging the life of a mesothelioma victim.
Chemotherapy is given in pill form or injected. In the case of mesothelioma patients, the drugs are given intrapleurally (into the chest cavity) or intraperitoneally (into the abdominal cavity). Doctors usually combine two drugs for the best result. Currently, the preferred combination is Alimta© (pemetrexed) and Cisplatin, but other drugs are used in tandem if deemed preferable for a specific patient. In some cases, patients can only tolerate a single drug so only one is used for treatment.
Other drugs are given to the patient to combat the unpleasant side effects of chemo, such as medication to relieve nausea and vomiting or vitamins to replace essential ones lost during chemotherapy.
Some patients decide that the side effects of chemotherapy are too severe and opt not to receive this treatment.
Clinical Trials
Mesothelioma Treatment
Clinical trials are the study of promising new treatments for a particular disease. These trials are constantly in need of patients who are willing to try these experimental treatments before they are approved by the FDA. Patients should speak to their doctors about current clinical trials available to them and if they might qualify to be a part of a particular study. Those opting to participate in a clinical trial should carefully weigh the pros and cons before agreeing to participate.
Alternative Therapies
Alternative therapies include potential treatment for a disease or its symptoms that are not part of the conventional treatment generally recommended for patients with the disease. These might include the use of vitamins or herbs or participation in therapies such as acupuncture, massage, or hypnosis.
Mesothelioma Treatment 1
A diagnosis of mesothelioma is always difficult, whether it is pleural mesothelioma or another variety. Because this is such an aggressive and stubborn form of cancer, patients and their families may have a difficult time addressing the issue of treatment, but because options for mesothelioma patients are steadily increasing, the discussion of treatment is quite important, even if all hope seems lost.
Each mesothelioma case is considered individually and there is no right or wrong treatment for the disease. What's best for you or your loved one will depend on a number of factors. Diagnostic tools such as x-rays, MRIs, CT scans, and biopsies will be used to determine these factors and these tests will assist the doctor and/or oncologist in determining the best treatment for the patient in question.
What are the Options?
Cancer treatment usually focuses upon destroying malignant cells and preserving healthy ones. This can be accomplished in a number of ways. At present, mesothelioma patients are faced with three major options for treatment of their disease - surgery, radiation, and chemotherapy. What course of treatment is recommended will largely depend on these issues:
* The type of mesothelioma and location of the tumor
* The size of the tumor(s)
* The degree to which the cancer has spread or metastasized
* The stage of the cancer - beginning, advanced, etc.
* The age of the patient
* The overall physical health of the patient
Setting up any type of treatment may involve seeing a variety of doctors, including an oncologist (cancer specialist), pulmonologist (lung specialist), or radiologist. Patience is sometimes necessary, but doctors will no doubt set up treatment as soon as possible after diagnosis.
Surgery
Surgery can be performed on mesothelioma patients for one of two reasons: in an attempt to cure the disease or for palliative reasons in order to keep the patient more comfortable and improve the quality of life. Unfortunately, because mesothelioma is almost always diagnosed in its late stages, curative surgery is not usually an option.
As tests are developed that may help to diagnose mesothelioma at an earlier stage, surgery may become more of an option in the future. At that point, doctors may be able to attempt to remove the cancer and some of the surrounding tissue in an attempt to stabilize the disease.
More often, however, surgery is used as a palliative measure. For example, doctors may opt for a surgery called a pleurodesis, which involves injecting talc into the lungs to prevent fluid from returning. A thoracentesis, a surgical procedure that removes fluid from the lungs by means of a thin needle, may also be recommended.
In severe cases, a pleurectomy may be recommended for palliative purposes. This involves removing the pleura - the lining of the lung - and can control fluid build-up and lessen pain and breathing difficulties.
Radiation Therapy
If a patients health is too fragile for surgery or chemotherapy, radiation is often recommended. Radiation causes the fewest side effects and is usually easier to tolerate than chemo. There are a few different forms of radiation therapy available to meso patients:
External beam radiation - the preferred type to treat mesothelioma, this type of radiation comes from a machine outside the body and is aimed toward affected areas. Usually administered 5-days-a-week for up to 5 weeks, this type of radiation is often used for palliative purposes - to lessen breathing difficulties, pain, bleeding, or difficulty swallowing - but seldom has much of an effect on the mesothelioma tumors. This type of radiation may also be used in addition to surgery.
Brachytherapy - Rarely prescribed for mesothelioma, this kind of radiation places radioactive material directly inside the lung or abdomen.
Chemotherapy
Like radiation, chemotherapy provides no cure for mesothelioma but can go a long way in providing relief from the horrendous symptoms of the disease. As researchers continue to test different combinations of chemotherapy drugs, patients continue to benefit from their findings, and someday, chemo may go a lot further in prolonging the life of a mesothelioma victim.
Chemotherapy is given in pill form or injected. In the case of mesothelioma patients, the drugs are given intrapleurally (into the chest cavity) or intraperitoneally (into the abdominal cavity). Doctors usually combine two drugs for the best result. Currently, the preferred combination is Alimta© (pemetrexed) and Cisplatin, but other drugs are used in tandem if deemed preferable for a specific patient. In some cases, patients can only tolerate a single drug so only one is used for treatment.
Other drugs are given to the patient to combat the unpleasant side effects of chemo, such as medication to relieve nausea and vomiting or vitamins to replace essential ones lost during chemotherapy.
Some patients decide that the side effects of chemotherapy are too severe and opt not to receive this treatment.
Clinical Trials
Mesothelioma Treatment
Clinical trials are the study of promising new treatments for a particular disease. These trials are constantly in need of patients who are willing to try these experimental treatments before they are approved by the FDA. Patients should speak to their doctors about current clinical trials available to them and if they might qualify to be a part of a particular study. Those opting to participate in a clinical trial should carefully weigh the pros and cons before agreeing to participate.
Alternative Therapies
Alternative therapies include potential treatment for a disease or its symptoms that are not part of the conventional treatment generally recommended for patients with the disease. These might include the use of vitamins or herbs or participation in therapies such as acupuncture, massage, or hypnosis.
Each mesothelioma case is considered individually and there is no right or wrong treatment for the disease. What's best for you or your loved one will depend on a number of factors. Diagnostic tools such as x-rays, MRIs, CT scans, and biopsies will be used to determine these factors and these tests will assist the doctor and/or oncologist in determining the best treatment for the patient in question.
What are the Options?
Cancer treatment usually focuses upon destroying malignant cells and preserving healthy ones. This can be accomplished in a number of ways. At present, mesothelioma patients are faced with three major options for treatment of their disease - surgery, radiation, and chemotherapy. What course of treatment is recommended will largely depend on these issues:
* The type of mesothelioma and location of the tumor
* The size of the tumor(s)
* The degree to which the cancer has spread or metastasized
* The stage of the cancer - beginning, advanced, etc.
* The age of the patient
* The overall physical health of the patient
Setting up any type of treatment may involve seeing a variety of doctors, including an oncologist (cancer specialist), pulmonologist (lung specialist), or radiologist. Patience is sometimes necessary, but doctors will no doubt set up treatment as soon as possible after diagnosis.
Surgery
Surgery can be performed on mesothelioma patients for one of two reasons: in an attempt to cure the disease or for palliative reasons in order to keep the patient more comfortable and improve the quality of life. Unfortunately, because mesothelioma is almost always diagnosed in its late stages, curative surgery is not usually an option.
As tests are developed that may help to diagnose mesothelioma at an earlier stage, surgery may become more of an option in the future. At that point, doctors may be able to attempt to remove the cancer and some of the surrounding tissue in an attempt to stabilize the disease.
More often, however, surgery is used as a palliative measure. For example, doctors may opt for a surgery called a pleurodesis, which involves injecting talc into the lungs to prevent fluid from returning. A thoracentesis, a surgical procedure that removes fluid from the lungs by means of a thin needle, may also be recommended.
In severe cases, a pleurectomy may be recommended for palliative purposes. This involves removing the pleura - the lining of the lung - and can control fluid build-up and lessen pain and breathing difficulties.
Radiation Therapy
If a patients health is too fragile for surgery or chemotherapy, radiation is often recommended. Radiation causes the fewest side effects and is usually easier to tolerate than chemo. There are a few different forms of radiation therapy available to meso patients:
External beam radiation - the preferred type to treat mesothelioma, this type of radiation comes from a machine outside the body and is aimed toward affected areas. Usually administered 5-days-a-week for up to 5 weeks, this type of radiation is often used for palliative purposes - to lessen breathing difficulties, pain, bleeding, or difficulty swallowing - but seldom has much of an effect on the mesothelioma tumors. This type of radiation may also be used in addition to surgery.
Brachytherapy - Rarely prescribed for mesothelioma, this kind of radiation places radioactive material directly inside the lung or abdomen.
Chemotherapy
Like radiation, chemotherapy provides no cure for mesothelioma but can go a long way in providing relief from the horrendous symptoms of the disease. As researchers continue to test different combinations of chemotherapy drugs, patients continue to benefit from their findings, and someday, chemo may go a lot further in prolonging the life of a mesothelioma victim.
Chemotherapy is given in pill form or injected. In the case of mesothelioma patients, the drugs are given intrapleurally (into the chest cavity) or intraperitoneally (into the abdominal cavity). Doctors usually combine two drugs for the best result. Currently, the preferred combination is Alimta© (pemetrexed) and Cisplatin, but other drugs are used in tandem if deemed preferable for a specific patient. In some cases, patients can only tolerate a single drug so only one is used for treatment.
Other drugs are given to the patient to combat the unpleasant side effects of chemo, such as medication to relieve nausea and vomiting or vitamins to replace essential ones lost during chemotherapy.
Some patients decide that the side effects of chemotherapy are too severe and opt not to receive this treatment.
Clinical Trials
Mesothelioma Treatment
Clinical trials are the study of promising new treatments for a particular disease. These trials are constantly in need of patients who are willing to try these experimental treatments before they are approved by the FDA. Patients should speak to their doctors about current clinical trials available to them and if they might qualify to be a part of a particular study. Those opting to participate in a clinical trial should carefully weigh the pros and cons before agreeing to participate.
Alternative Therapies
Alternative therapies include potential treatment for a disease or its symptoms that are not part of the conventional treatment generally recommended for patients with the disease. These might include the use of vitamins or herbs or participation in therapies such as acupuncture, massage, or hypnosis.
Asbestos Cancer
Mesothelioma is sometimes referred to asbestos cancer. It is referred to this because the only known cause of mesothelioma is exposure to asbestos. Asbestos exposure causes mesothelioma in different ways depending on the variety of the malignancy.
Pleural Mesothelioma and Asbestos
Pleural mesothelioma, the most common variety, is caused by inhaled asbestos fibers which lodge themselves in the pleural lining of the lungs. Asbestos fibers, which are microscopic but durable, then irritate the inner tissue, causing the growth of harmful scar tissue and eventually mesothelioma.
Peritoneal Mesothelioma and Asbestos
Peritoneal mesothelioma is less common and doctors have not exacted relationship between the asbestos exposure and the malignancy. However, nearly all peritoneal mesothelioma patients have a history of asbestos exposure. Peritoneal mesothelioma occurs in the lining of the abdominal cavity, near the digestive tract. Doctors surmise that ingested asbestos fibers lodge in the outer tissue of the organs and cause a similar inflammation as in the pleura.
Pericardial Mesothelioma and Asbestos
Pericardial mesothelioma occurs in the lining of the heart and is extremely rare. Like peritoneal mesothelioma, very little is known about the relationship between the malignancy and asbestos exposure but nearly all patients have asbestos exposure history. Physicians surmise that because the cancer occurs in the heart’s lining, the asbestos fibers may impact the heart through the bloodstream.
Lung Cancer and Asbestos
Asbestos has also been linked to cancers of the lung, as opposed to the pleural lining of the lungs. These are likely the result of malfunction caused due the exposure and inhalation of asbestos fibers, which can also cause chronic respiratory conditions such as asbestosis.
Pleural Mesothelioma and Asbestos
Pleural mesothelioma, the most common variety, is caused by inhaled asbestos fibers which lodge themselves in the pleural lining of the lungs. Asbestos fibers, which are microscopic but durable, then irritate the inner tissue, causing the growth of harmful scar tissue and eventually mesothelioma.
Peritoneal Mesothelioma and Asbestos
Peritoneal mesothelioma is less common and doctors have not exacted relationship between the asbestos exposure and the malignancy. However, nearly all peritoneal mesothelioma patients have a history of asbestos exposure. Peritoneal mesothelioma occurs in the lining of the abdominal cavity, near the digestive tract. Doctors surmise that ingested asbestos fibers lodge in the outer tissue of the organs and cause a similar inflammation as in the pleura.
Pericardial Mesothelioma and Asbestos
Pericardial mesothelioma occurs in the lining of the heart and is extremely rare. Like peritoneal mesothelioma, very little is known about the relationship between the malignancy and asbestos exposure but nearly all patients have asbestos exposure history. Physicians surmise that because the cancer occurs in the heart’s lining, the asbestos fibers may impact the heart through the bloodstream.
Lung Cancer and Asbestos
Asbestos has also been linked to cancers of the lung, as opposed to the pleural lining of the lungs. These are likely the result of malfunction caused due the exposure and inhalation of asbestos fibers, which can also cause chronic respiratory conditions such as asbestosis.
What is Asbestos?
For most individuals, especially those born in the last 40 years, the mention of asbestos conjures up thoughts of a dangerous substance that's sickened many people and caused myriad deaths around the world. That's an accurate description.
A common misconception on the part of many individuals, however, is that asbestos is a hazardous man-made substance, conjured up in factories around the world for commercial use. The truth is, however, that asbestos is a naturally-occurring mineral that can be found in hundreds of countries on just about every continent. As a matter of fact, asbestos is still mined in several of these countries, including Canada and Russia. Other countries have outlawed the mining of asbestos.
Asbestos is a highly-fibrous mineral with long, thin, separable fibers. The thin fibers can be spun and woven together, and possess valuable heat-resistant properties that make asbestos suitable for insulation and other such products. Indeed, for decades, asbestos was the material of choice for many industries that were manufacturing products for which heat resistance, low electrical conductivity, flexibility, and high tensile strength were essential factors. Today, there are other alternatives.
There are two kinds of asbestos. The serpentine variety is curly. Chrysotile asbestos, most commonly used for industrial purposes, is from the serpentine family. Other asbestos fibers, from the amphibole family, are very straight and needle-like. Amosite, crocidolite, tremolite, actinolite, and anthophyllite are amphibole asbestos varieties.
Currently, chrysotile asbestos is the only type mined on a wide-scale though a handful of countries continue to mine other forms. However, worldwide outrage about the use of dangerous asbestos has forced many countries to reconsider their position on mining.
Why is Asbestos a Health Concern?
Studies estimate that approximately 3,000 different types of commercial products include asbestos. In and of itself, the mineral is not harmful, as long as it's intact. However, when the asbestos in these products is damaged and the fibers become airborne, concerns begin to arise.
"Friable" asbestos - that which is dry and can be easily crumbled with the hand - is the culprit. Such asbestos is more likely to release fibers into the air. Spray-applied asbestos fireproofing, which was used in millions of buildings throughout the world, is of the friable variety. However, some non-friable asbestos can also release airborne fibers, particularly when sanded, chopped, hammered, cut, or otherwise manipulated. That's why, when demolishing a building that contains asbestos, proper removal and disposal in a designated asbestos landfill is essential before the building is torn down.
Why are Airborne Fibers Dangerous?
Inhaled asbestos fibers remain in the body and cannot be expelled. Because of this, the fibers can easily penetrate body tissues and may deposit themselves in airways and in the lung tissue. The more you're exposed, the more likely you might develop an asbestos-related disease. Most people exposed to asbestos on a very casual basis probably will not develop such a disease.
Once the fibers are lodged in the body, they will cause inflammation which may eventually result in the formation of cancerous tumors, particularly on the mesothelium - the lining of the lungs. Other affected areas may include the peritoneum - the lining of the abdomen - and the pericardium - the lining around the heart. There are various type of mesothelioma treatment options for each type.
With some recent exceptions found in workers at the World Trade Center disaster, asbestos-related diseases, such as pleural mesothelioma, usually take decades to surface. That's why current cases of mesothelioma and other asbestos-related diseases involve many individuals who were employed in shipyards during World War II, performing jobs that exposed them to friable asbestos on a daily basis. Shipyard workers are among those most affected by aggressive asbestos cancer.
Is Asbestos Banned?
Contrary to what many people believe, asbestos is not and has never been banned in the United States. In 1976, Congress passed a law to regulate toxic substances (known as the Toxic Substances Control Act) but a total ban was not suggested. In 1989, the Environmental Protection Agency finalized regulations to ban asbestos under the aforementioned act, but two years later, a New Orleans circuit court of appeal overturned the regulation. The result was that new uses of the dangerous mineral were banned but old ones remained.
Many other industrialized nations have banned asbestos including the European Union and a handful of other countries, such as Chile, Croatia, Australia, Argentina, and Saudi Arabia. Several countries, especially those who continue to make money from the mining of asbestos, consistently fight against asbestos bans.
21-06-09
What is Mesothelioma?
Throughout the past decade, the term "mesothelioma" has become more and more recognizable. Once an obscure disease that meant little to the general public, mention of this disease now conjures up thoughts and pictures of factories and mines strewn with asbestos and the unfortunate workers who were employed in those dangerous places.
Thanks to concerned medical professionals, researchers, and watchdog organizations, we're learning more and more about mesothelioma and how it affects the lives of those who are afflicted. However, there's still far to go as both better treatments and a cure for the disease are sought.
About the Disease
Simply put, mesothelioma which is commonly referred to as asbestos cancer, is an aggressive cancer caused primarily by the inhalation of dangerous asbestos fibers. The disease attacks the mesothelium, a protective, two-layered membrane that covers the internal organs of the body including the lungs, heart and abdominal organs. Between these layers, the cells produce fluid, which allows easy movement of the heart and lungs within the chest cavity. The layer that covers the lungs is called the pleura, and the layer that covers the heart is called the pericardium. The peritoneum lines the abdominal cavity. Mesothelium also lines the male and female reproductive organs. Mesothelioma can affect any of these cells, but is usually seen in the pleural or peritoneal mesothelium. The most commonly diagnosed form of this cancer is pleural mesothelioma.
Mesothelioma takes anywhere from 20 to 50 years to develop, which is why older individuals are usually the victims. However, recent cases involving September 11th World Trade Center first responders and clean-up crews show that high concentrations of asbestos can cause the disease to develop much more rapidly. A few WTC workers have already died of the disease.
Effects of the Disease
The invasion of the mesothelium by cancer cells makes it very difficult for the patient to breathe, resulting in the need for oxygen, especially as the disease progresses. Those with the pleural form of mesothelioma may also suffer from pleural effusions. These effusions prevent the smooth movement of the lungs and other organs in the chest. Peritoneal mesothelioma also affects the stomach area and abdominal cavity, causing nausea, vomiting, or loss of appetite, which can result in dangerous weight loss. In addition to breathing difficulties and loss of appetite, mesothelioma victims also complain of excessive coughing, sleeping difficulties, persistent chest pain, fever, and pain in the lower back.
Mesothelioma, in general, is a very painful disease and because it is usually not diagnosed until it's in an advanced stage. For this reason, the symptoms are typically quite serious. Late diagnosis also means that the cancer is more likely to have metastasized, or spread, making successful mesothelioma treatment even more difficult.
Who Gets Mesothelioma?
Statistics show that, because of their work history, the disease most often affects men between the ages of 50 and 70 who were employed in an asbestos-laden environment before asbestos warnings and bans were in place in the 1970s. Though women still have a much lower frequency of the disease, cases of second-hand exposure to asbestos has prompted more diagnoses among women, especially those whose male family members worked with asbestos. The occupations most associated with mesothelioma are shipyard workers, electricians, plumbers, construction industry workers, pipefitters, boilermakers, and anyone subject to heavy exposure to dangerous asbestos and airborne asbestos fibers.
An abundance of cases have also demonstrated that mesothelioma can develop among people who lived in communities where asbestos factories or mines were located. In some instances, entire towns have been adversely affected by the presence of asbestos fibers in the air. For example, in Libby, Montana - site of a former vermiculite asbestos mine - hundreds have already died of mesothelioma.
Though still significantly rarer than other cancers, an estimated 2,000 to 3,000 new cases of mesothelioma are diagnosed each year in the United States. Other countries, notably the United Kingdom and Australia, report a much higher incidence of the disease. Nevertheless, the United States - like many other countries - has seen an increase in asbestos-caused cancer as men who worked in U.S. shipyards in the 1940s and 1950s, at the height of production, are now being diagnosed with mesothelioma.
Dealing with Mesothelioma
Mesothelioma is most often diagnosed in its late stages, and such a diagnosis is devastating to the individual and his/her family. Though research into the disease has been ongoing, there is currently no cure for mesothelioma. Some patients may be candidates for surgery to remove tumors or even an entire lung, but most are better treated with radiation or chemotherapy. More often than not, these treatments are palliative, serving to lessen the severity of the symptoms of the disease rather than offering a cure.
Medical professionals and research scientists, however, are constantly exploring new ways to combat the disease. For example, doctors know that some combinations of chemotherapy drugs work better than others and tests developed to ascertain earlier diagnosis of the disease or to monitor those most at risk have arrived on the scene.
Who's to Blame?
The reason someone develops mesothelioma is usually the lack of proper protection offered to those who worked with asbestos. Though the dangerous properties of asbestos and asbestos products have been evident for decades, many employers neglected to protect their workers from inhaling asbestos while on the job. It wasn't until public awareness of the dangers of the material were revealed in the 1970s that many employers began offering protective clothing such as respirators, gloves, aprons, and other such items to those working with asbestos on a daily basis.
Due to the negligence of employers, many companies who manufacture asbestos or products that contain asbestos have been subject to literally thousands of lawsuits filed by those who've been harmed by the material. Many of those lawsuits have come from individuals suffering from mesothelioma.
Saturday, June 13, 2009
TRADES AT RISK
Uses of Asbestos
"You have done what no one else has ever done for us and that is you made our lives a whole lot easier. We give thanks to God for your life each day."- Client of Blumenthal & Gruber, LLP
Asbestos has been used in many industries. The building and construction industry has used asbestos for strengthening cement and plastics as well as for insulation, fireproofing, and sound absorption. Asbestos has also been used to insulate boilers, steam pipes, and hot water pipes in the shipbuilding and construction industry. The automotive industry has used asbestos in vehicle brake shoes and clutch pads.
There are thousands of products that have contained asbestos, including the following:
Construction products, including joint compound, plaster, sheetrock, ceiling and floor tile; gaskets and packings; paints, coatings, and adhesives; caulking and patching tape; plastics; vermiculite-containing consumer garden products;
Insulation products, such as block insulation, castables, boilers, pipe covering, table pads and heat-protective mats, heat and electrical wire insulation, industrial filters for beverages, underlying material for sheet flooring, firebrick, gunnite, and transite siding;
Asbestos cement sheet and pipe products used for water supply and sewage piping, roofing and siding, casings for electrical wires, fire protection material, electrical switchboards and components, and residential and industrial building materials;
Friction products, including clutch facings, brake linings for automobiles, gaskets, and industrial friction materials; and
Asbestos textile products, such as packing components, roofing materials, heat- and fire-resistant fabrics (including blankets and curtains), and felt.
Malignant mesothelioma can be caused by the use of the above asbestos-containing products.
Workers at Risk
Many people are exposed to asbestos at some time in their lives; however, most do not become ill from their exposure. The risk to workers exposed to asbestos depends on several factors:
Length of exposure
Concentration of asbestos fibers in the air
Whether or not protective equipment was worn
Workers may be exposed when asbestos-containing products are manufactured or installed. Research has found asbestos-related diseases in individuals with only brief exposure histories. Generally, those who develop asbestos-related diseases show no signs of illness for a long time after their first exposure. It can take anywhere from 10 to 40 years for symptoms of an asbestos-related condition to appear.
In addition to those exposed occupationally, family members of workers heavily exposed to asbestos face an increased risk of developing mesothelioma. This risk results from exposure to asbestos fibers brought into the home on clothing, shoes, hair, and skin of workers. This type of exposure is called paraoccupational or household exposure.
Health hazards from asbestos fibers have been recognized in the following industries and job sites:
Asbestos mining, milling and product manufacturing (building, insulation, roofing)
Automotive repair (brakes and clutches)
"You have done what no one else has ever done for us and that is you made our lives a whole lot easier. We give thanks to God for your life each day."- Client of Blumenthal & Gruber, LLP
Asbestos has been used in many industries. The building and construction industry has used asbestos for strengthening cement and plastics as well as for insulation, fireproofing, and sound absorption. Asbestos has also been used to insulate boilers, steam pipes, and hot water pipes in the shipbuilding and construction industry. The automotive industry has used asbestos in vehicle brake shoes and clutch pads.
There are thousands of products that have contained asbestos, including the following:
Construction products, including joint compound, plaster, sheetrock, ceiling and floor tile; gaskets and packings; paints, coatings, and adhesives; caulking and patching tape; plastics; vermiculite-containing consumer garden products;
Insulation products, such as block insulation, castables, boilers, pipe covering, table pads and heat-protective mats, heat and electrical wire insulation, industrial filters for beverages, underlying material for sheet flooring, firebrick, gunnite, and transite siding;
Asbestos cement sheet and pipe products used for water supply and sewage piping, roofing and siding, casings for electrical wires, fire protection material, electrical switchboards and components, and residential and industrial building materials;
Friction products, including clutch facings, brake linings for automobiles, gaskets, and industrial friction materials; and
Asbestos textile products, such as packing components, roofing materials, heat- and fire-resistant fabrics (including blankets and curtains), and felt.
Malignant mesothelioma can be caused by the use of the above asbestos-containing products.
Workers at Risk
Many people are exposed to asbestos at some time in their lives; however, most do not become ill from their exposure. The risk to workers exposed to asbestos depends on several factors:
Length of exposure
Concentration of asbestos fibers in the air
Whether or not protective equipment was worn
Workers may be exposed when asbestos-containing products are manufactured or installed. Research has found asbestos-related diseases in individuals with only brief exposure histories. Generally, those who develop asbestos-related diseases show no signs of illness for a long time after their first exposure. It can take anywhere from 10 to 40 years for symptoms of an asbestos-related condition to appear.
In addition to those exposed occupationally, family members of workers heavily exposed to asbestos face an increased risk of developing mesothelioma. This risk results from exposure to asbestos fibers brought into the home on clothing, shoes, hair, and skin of workers. This type of exposure is called paraoccupational or household exposure.
Health hazards from asbestos fibers have been recognized in the following industries and job sites:
Asbestos mining, milling and product manufacturing (building, insulation, roofing)
Automotive repair (brakes and clutches)
- Chemical plants
- Construction sites
- Foundries
- Navy ships
- Paper mills
- Power plants
- Refineries
- Shipyards and ships
- Steel mills
- Aluminum plant workers
- Auto mechanics
- Boilermakers
- Bricklayers
- Carpenters
- Drywall installers
- Electricians
- Furnace operators
- Industrial workers
- Insulators
- Iron workers
- Laborers
- Maintenance workers
- Millwrights
- Navy personnel
- Operators
- Painters
- Pipefitters
- Plasterers
- Plumbers
- Refinery workers
- Roofers
- Sheet metal workers
- Shipyard workers
- Steamfitters
- Steelworkers
- Tile setters
- Welders and a variety of other trades
Recurrent Malignant Mesothelioma
Treatment depends on many factors, including where the cancer came back and what treatment the patient received before. Clinical trials are testing new treatments.
Are new treatments for mesothelioma being studied?
Yes. Because mesothelioma is very hard to control, the National Cancer Institute (NCI) is sponsoring clinical trials (research studies with people) that are designed to find new treatments and better ways to use current treatments. Before any new treatment can be recommended for general use, doctors conduct clinical trials to find out whether the treatment is safe for patients and effective against the disease. Participation in clinical trials is an important treatment option for many patients with mesothelioma.
People interested in taking part in a clinical trial should talk with their doctor. Information about clinical trials is available from the Cancer Information Service (CIS) (see below) at 1-800-4-CANCER. Information specialists at the CIS use PDQ�, NCI's cancer information database, to identify and provide detailed information about specific ongoing clinical trials. Patients also have the option of searching for clinical trials on their own. The clinical trials page on the NCI's Cancer.gov Web site, located at http://cancer.gov/clinical_trials on the Internet, provides general information about clinical trials and links to PDQ.
People considering clinical trials may be interested in the NCI booklet Taking Part in Clinical Trials: What Cancer Patients Need To Know. This booklet describes how research studies are carried out and explains their possible benefits and risks. The booklet is available by calling the CIS, or from the NCI Publications
Are new treatments for mesothelioma being studied?
Yes. Because mesothelioma is very hard to control, the National Cancer Institute (NCI) is sponsoring clinical trials (research studies with people) that are designed to find new treatments and better ways to use current treatments. Before any new treatment can be recommended for general use, doctors conduct clinical trials to find out whether the treatment is safe for patients and effective against the disease. Participation in clinical trials is an important treatment option for many patients with mesothelioma.
People interested in taking part in a clinical trial should talk with their doctor. Information about clinical trials is available from the Cancer Information Service (CIS) (see below) at 1-800-4-CANCER. Information specialists at the CIS use PDQ�, NCI's cancer information database, to identify and provide detailed information about specific ongoing clinical trials. Patients also have the option of searching for clinical trials on their own. The clinical trials page on the NCI's Cancer.gov Web site, located at http://cancer.gov/clinical_trials on the Internet, provides general information about clinical trials and links to PDQ.
People considering clinical trials may be interested in the NCI booklet Taking Part in Clinical Trials: What Cancer Patients Need To Know. This booklet describes how research studies are carried out and explains their possible benefits and risks. The booklet is available by calling the CIS, or from the NCI Publications
How common is mesothelioma?
Although reported incidence rates have increased in the past 20 years, mesothelioma is still a relatively rare cancer. About 2,000 new cases of mesothelioma are diagnosed in the United States each year. Mesothelioma occurs more often in men than in women and risk increases with age, but this disease can appear in either men or women at any age.
What are the risk factors for mesothelioma?
Working with asbestos is the major risk factor for mesothelioma. A history of asbestos exposure at work is reported in about 70 percent to 80 percent of all cases. However, mesothelioma has been reported in some individuals without any known exposure to asbestos.
Asbestos is the name of a group of minerals that occur naturally as masses of strong, flexible fibers that can be separated into thin threads and woven. Asbestos has been widely used in many industrial products, including cement, brake linings, roof shingles, flooring products, textiles, and insulation. If tiny asbestos particles float in the air, especially during the manufacturing process, they may be inhaled or swallowed, and can cause serious health problems. In addition to mesothelioma, exposure to asbestos increases the risk of lung cancer, asbestosis (a noncancerous, chronic lung ailment), and other cancers, such as those of the larynx and kidney.
Smoking does not appear to increase the risk of mesothelioma. However, the combination of smoking and asbestos exposure significantly increases a person's risk of developing cancer of the air passageways in the lung.
What are the symptoms of mesothelioma?
Symptoms of mesothelioma may not appear until 30 to 50 years after exposure to asbestos. Shortness of breath and pain in the chest due to an accumulation of fluid in the pleura are often symptoms of pleural mesothelioma. Symptoms of peritoneal mesothelioma include weight loss and abdominal pain and swelling due to a buildup of fluid in the abdomen. Other symptoms of peritoneal mesothelioma may include bowel obstruction, blood clotting abnormalities, anemia, and fever. If the cancer has spread beyond the mesothelium to other parts of the body, symptoms may include pain, trouble swallowing, or swelling of the neck or face.
These symptoms may be caused by mesothelioma or by other, less serious conditions. It is important to see a doctor about any of these symptoms. Only a doctor can make a diagnosis.
How is mesothelioma diagnosed?
Diagnosing mesothelioma is often difficult, because the symptoms are similar to those of a number of other conditions. Diagnosis begins with a review of the patient's medical history, including any history of asbestos exposure. A complete physical examination may be performed, including x-rays of the chest or abdomen and lung function tests. A CT (or CAT) scan or an MRI may also be useful. A CT scan is a series of detailed pictures of areas inside the body created by a computer linked to an x-ray machine. In an MRI, a powerful magnet linked to a computer is used to make detailed pictures of areas inside the body. These pictures are viewed on a monitor and can also be printed.
A biopsy is needed to confirm a diagnosis of mesothelioma. In a biopsy, a surgeon or a medical oncologist (a doctor who specializes in diagnosing and treating cancer) removes a sample of tissue for examination under a microscope by a pathologist. A biopsy may be done in different ways, depending on where the abnormal area is located. If the cancer is in the chest, the doctor may perform a thoracoscopy. In this procedure, the doctor makes a small cut through the chest wall and puts a thin, lighted tube called a thoracoscope into the chest between two ribs. Thoracoscopy allows the doctor to look inside the chest and obtain tissue samples. If the cancer is in the abdomen, the doctor may perform a peritoneoscopy. To obtain tissue for examination, the doctor makes a small opening in the abdomen and inserts a special instrument called a peritoneoscope into the abdominal cavity. If these procedures do not yield enough tissue, more extensive diagnostic surgery may be necessary.
If the diagnosis is mesothelioma, the doctor will want to learn the stage (or extent) of the disease. Staging involves more tests in a careful attempt to find out whether the cancer has spread and, if so, to which parts of the body. Knowing the stage of the disease helps the doctor plan treatment.
Mesothelioma is described as localized if the cancer is found only on the membrane surface where it originated. It is classified as advanced if it has spread beyond the original membrane surface to other parts of the body, such as the lymph nodes, lungs, chest wall, or abdominal organs.
What are the stages of mesothelioma?
Once malignant mesothelioma is found, more tests will be done to find out if cancer cells have spread to other parts of the body. This is called staging. A doctor needs to know the stage of the cancer to plan treatment. The following stages are used for malignant mesothelioma.
Localized malignant mesothelioma Stage I The cancer is found in the lining of the chest cavity near the lung and heart or in the diaphragm or the lung.
Advanced malignant mesothelioma Stage II The cancer has spread beyond the lining of the chest to lymph nodes in the chest.
Stage III Cancer has spread into the chest wall, center of the chest, heart, through the diaphragm, or abdominal lining, and in some cases into nearby lymph nodes.
Stage IV Cancer has spread to distant organs or tissues.
Recurrent malignant mesothelioma Recurrent disease means that the cancer has come back (recurred) after it has been treated. It may come back in the lining of the chest or abdomen or in another part of the body.
How is mesothelioma treated?
Treatment for mesothelioma depends on the location of the cancer, the stage of the disease, and the patient's age and general health. Standard treatment options include surgery, radiation therapy, and chemotherapy. Sometimes, these treatments are combined.
Surgery is a common treatment for mesothelioma. The doctor may remove part of the lining of the chest or abdomen and some of the tissue around it. For cancer of the pleura (pleural mesothelioma), a lung may be removed in an operation called a pneumonectomy. Sometimes part of the diaphragm, the muscle below the lungs that helps with breathing, is also removed.
Radiation therapy, also called radiotherapy, involves the use of high-energy rays to kill cancer cells and shrink tumors. Radiation therapy affects the cancer cells only in the treated area. The radiation may come from a machine (external radiation) or from putting materials that produce radiation through thin plastic tubes into the area where the cancer cells are found (internal radiation therapy).
Chemotherapy is the use of anticancer drugs to kill cancer cells throughout the body. Most drugs used to treat mesothelioma are given by injection into a vein (intravenous, or IV). Doctors are also studying the effectiveness of putting chemotherapy directly into the chest or abdomen (intracavitary chemotherapy).
Intraoperative photodynamic therapy is a new type of treatment that uses special drugs and light to kill cancer cells during surgery. A drug that makes cancer cells more sensitive to light is injected into a vein several days before surgery. During surgery to remove as much of the cancer as possible, a special light is used to shine on the pleura. This treatment is being studied for early stages of mesothelioma in the chest.
To relieve symptoms and control pain, the doctor may use a needle or a thin tube to drain fluid that has built up in the chest or abdomen. The procedure for removing fluid from the chest is called thoracentesis. Removal of fluid from the abdomen is called paracentesis. Drugs may be given through a tube in the chest to prevent more fluid from accumulating. Radiation therapy and surgery may also be helpful in relieving symptoms.
What treatments are used at the different stagesof mesothelioma?
Treatment depends on where the cancer is, how far it has spread, and the patient's age and general health. Standard treatment may be considered because of its effectiveness in patients in past studies, or participation in a clinical trial may be considered. Not all patients are cured with standard therapy and some standard treatments may have more side effects than are desired. For these reasons, clinical trials are designed to find better ways to treat cancer patients and are based on the most up-to-date information. Clinical trials are ongoing in many parts of the country for many patients with malignant mesothelioma. To learn more about clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237); TTY at 1-800-332-8615.
Localized Malignant Mesothelioma (Stage I) If the cancer is only in one place in the chest or abdomen, treatment will probably be surgery to remove part of the pleura and some of the tissue around it.
If the cancer is found in a larger part of the pleura, treatment may be one of the following:
Surgery to remove the pleura and the tissue near it to relieve symptoms, with or without radiation therapy after surgery.
Surgery to remove sections of the pleura, the lung, part of the diaphragm, and part of the lining around the heart.
External beam radiation therapy to relieve symptoms.
A clinical trial of surgery followed by chemotherapy given inside the chest.
A clinical trial of surgery, radiation therapy, and/or chemotherapy.
Advanced Malignant Mesothelioma (Stages II, III, and IV) Treatment may be one of the following:
Draining of fluid in the chest or abdomen (thoracentesis or paracentesis) to reduce discomfort. Drugs also may be put into the chest or abdomen to prevent further collection of fluid.
Surgery to relieve symptoms.
Radiation therapy to relieve symptoms.
Chemotherapy.
A clinical trial of surgery, radiation therapy, and chemotherapy.
Chemotherapy given in the chest or abdomen.
What are the risk factors for mesothelioma?
Working with asbestos is the major risk factor for mesothelioma. A history of asbestos exposure at work is reported in about 70 percent to 80 percent of all cases. However, mesothelioma has been reported in some individuals without any known exposure to asbestos.
Asbestos is the name of a group of minerals that occur naturally as masses of strong, flexible fibers that can be separated into thin threads and woven. Asbestos has been widely used in many industrial products, including cement, brake linings, roof shingles, flooring products, textiles, and insulation. If tiny asbestos particles float in the air, especially during the manufacturing process, they may be inhaled or swallowed, and can cause serious health problems. In addition to mesothelioma, exposure to asbestos increases the risk of lung cancer, asbestosis (a noncancerous, chronic lung ailment), and other cancers, such as those of the larynx and kidney.
Smoking does not appear to increase the risk of mesothelioma. However, the combination of smoking and asbestos exposure significantly increases a person's risk of developing cancer of the air passageways in the lung.
What are the symptoms of mesothelioma?
Symptoms of mesothelioma may not appear until 30 to 50 years after exposure to asbestos. Shortness of breath and pain in the chest due to an accumulation of fluid in the pleura are often symptoms of pleural mesothelioma. Symptoms of peritoneal mesothelioma include weight loss and abdominal pain and swelling due to a buildup of fluid in the abdomen. Other symptoms of peritoneal mesothelioma may include bowel obstruction, blood clotting abnormalities, anemia, and fever. If the cancer has spread beyond the mesothelium to other parts of the body, symptoms may include pain, trouble swallowing, or swelling of the neck or face.
These symptoms may be caused by mesothelioma or by other, less serious conditions. It is important to see a doctor about any of these symptoms. Only a doctor can make a diagnosis.
How is mesothelioma diagnosed?
Diagnosing mesothelioma is often difficult, because the symptoms are similar to those of a number of other conditions. Diagnosis begins with a review of the patient's medical history, including any history of asbestos exposure. A complete physical examination may be performed, including x-rays of the chest or abdomen and lung function tests. A CT (or CAT) scan or an MRI may also be useful. A CT scan is a series of detailed pictures of areas inside the body created by a computer linked to an x-ray machine. In an MRI, a powerful magnet linked to a computer is used to make detailed pictures of areas inside the body. These pictures are viewed on a monitor and can also be printed.
A biopsy is needed to confirm a diagnosis of mesothelioma. In a biopsy, a surgeon or a medical oncologist (a doctor who specializes in diagnosing and treating cancer) removes a sample of tissue for examination under a microscope by a pathologist. A biopsy may be done in different ways, depending on where the abnormal area is located. If the cancer is in the chest, the doctor may perform a thoracoscopy. In this procedure, the doctor makes a small cut through the chest wall and puts a thin, lighted tube called a thoracoscope into the chest between two ribs. Thoracoscopy allows the doctor to look inside the chest and obtain tissue samples. If the cancer is in the abdomen, the doctor may perform a peritoneoscopy. To obtain tissue for examination, the doctor makes a small opening in the abdomen and inserts a special instrument called a peritoneoscope into the abdominal cavity. If these procedures do not yield enough tissue, more extensive diagnostic surgery may be necessary.
If the diagnosis is mesothelioma, the doctor will want to learn the stage (or extent) of the disease. Staging involves more tests in a careful attempt to find out whether the cancer has spread and, if so, to which parts of the body. Knowing the stage of the disease helps the doctor plan treatment.
Mesothelioma is described as localized if the cancer is found only on the membrane surface where it originated. It is classified as advanced if it has spread beyond the original membrane surface to other parts of the body, such as the lymph nodes, lungs, chest wall, or abdominal organs.
What are the stages of mesothelioma?
Once malignant mesothelioma is found, more tests will be done to find out if cancer cells have spread to other parts of the body. This is called staging. A doctor needs to know the stage of the cancer to plan treatment. The following stages are used for malignant mesothelioma.
Localized malignant mesothelioma Stage I The cancer is found in the lining of the chest cavity near the lung and heart or in the diaphragm or the lung.
Advanced malignant mesothelioma Stage II The cancer has spread beyond the lining of the chest to lymph nodes in the chest.
Stage III Cancer has spread into the chest wall, center of the chest, heart, through the diaphragm, or abdominal lining, and in some cases into nearby lymph nodes.
Stage IV Cancer has spread to distant organs or tissues.
Recurrent malignant mesothelioma Recurrent disease means that the cancer has come back (recurred) after it has been treated. It may come back in the lining of the chest or abdomen or in another part of the body.
How is mesothelioma treated?
Treatment for mesothelioma depends on the location of the cancer, the stage of the disease, and the patient's age and general health. Standard treatment options include surgery, radiation therapy, and chemotherapy. Sometimes, these treatments are combined.
Surgery is a common treatment for mesothelioma. The doctor may remove part of the lining of the chest or abdomen and some of the tissue around it. For cancer of the pleura (pleural mesothelioma), a lung may be removed in an operation called a pneumonectomy. Sometimes part of the diaphragm, the muscle below the lungs that helps with breathing, is also removed.
Radiation therapy, also called radiotherapy, involves the use of high-energy rays to kill cancer cells and shrink tumors. Radiation therapy affects the cancer cells only in the treated area. The radiation may come from a machine (external radiation) or from putting materials that produce radiation through thin plastic tubes into the area where the cancer cells are found (internal radiation therapy).
Chemotherapy is the use of anticancer drugs to kill cancer cells throughout the body. Most drugs used to treat mesothelioma are given by injection into a vein (intravenous, or IV). Doctors are also studying the effectiveness of putting chemotherapy directly into the chest or abdomen (intracavitary chemotherapy).
Intraoperative photodynamic therapy is a new type of treatment that uses special drugs and light to kill cancer cells during surgery. A drug that makes cancer cells more sensitive to light is injected into a vein several days before surgery. During surgery to remove as much of the cancer as possible, a special light is used to shine on the pleura. This treatment is being studied for early stages of mesothelioma in the chest.
To relieve symptoms and control pain, the doctor may use a needle or a thin tube to drain fluid that has built up in the chest or abdomen. The procedure for removing fluid from the chest is called thoracentesis. Removal of fluid from the abdomen is called paracentesis. Drugs may be given through a tube in the chest to prevent more fluid from accumulating. Radiation therapy and surgery may also be helpful in relieving symptoms.
What treatments are used at the different stagesof mesothelioma?
Treatment depends on where the cancer is, how far it has spread, and the patient's age and general health. Standard treatment may be considered because of its effectiveness in patients in past studies, or participation in a clinical trial may be considered. Not all patients are cured with standard therapy and some standard treatments may have more side effects than are desired. For these reasons, clinical trials are designed to find better ways to treat cancer patients and are based on the most up-to-date information. Clinical trials are ongoing in many parts of the country for many patients with malignant mesothelioma. To learn more about clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237); TTY at 1-800-332-8615.
Localized Malignant Mesothelioma (Stage I) If the cancer is only in one place in the chest or abdomen, treatment will probably be surgery to remove part of the pleura and some of the tissue around it.
If the cancer is found in a larger part of the pleura, treatment may be one of the following:
Surgery to remove the pleura and the tissue near it to relieve symptoms, with or without radiation therapy after surgery.
Surgery to remove sections of the pleura, the lung, part of the diaphragm, and part of the lining around the heart.
External beam radiation therapy to relieve symptoms.
A clinical trial of surgery followed by chemotherapy given inside the chest.
A clinical trial of surgery, radiation therapy, and/or chemotherapy.
Advanced Malignant Mesothelioma (Stages II, III, and IV) Treatment may be one of the following:
Draining of fluid in the chest or abdomen (thoracentesis or paracentesis) to reduce discomfort. Drugs also may be put into the chest or abdomen to prevent further collection of fluid.
Surgery to relieve symptoms.
Radiation therapy to relieve symptoms.
Chemotherapy.
A clinical trial of surgery, radiation therapy, and chemotherapy.
Chemotherapy given in the chest or abdomen.
MESOTHELIOMA Q & A
The Mesothelioma Information Source is designed to provide resources and peace of mind for people with mesothelioma and their families. Our goal is to provide straightforward, honest and meaningful assistance during a difficult time. The lawyers at Blumenthal & Gruber, LLP are available to answer any questions or concerns you have about the legal process.
The first step in any successful battle against mesothelioma is to become informed. Please visit our mesothelioma treatment options page to assist you in finding mesothelioma specialists or simply call us and we will be glad to discuss a variety of treatment options with you.
At Blumenthal and Gruber, LLP we pride ourselves in our personal and ongoing relationships with our clients and their families. Our clients page will allow you to hear from some of the people we have helped and learn more about the lawyers at our firm.
As attorneys who have dedicated their careers to fighting for the rights of industrial disease victims, our job is to hold the asbestos companies accountable for the harm they have caused.
Mesothelioma is a rare form of cancer in which malignant (cancerous) cells are found in the mesothelium, a protective sac that covers most of the body's internal organs. Most people who develop mesothelioma have worked on jobs where they inhaled asbestos particles.
What is the mesothelium?
The mesothelium is a membrane that covers and protects most of the internal organs of the body. It is composed of two layers of cells: One layer immediately surrounds the organ; the other forms a sac around it. The mesothelium produces a lubricating fluid that is released between these layers, allowing moving organs (such as the beating heart and the expanding and contracting lungs) to glide easily against adjacent structures.
The mesothelium has different names, depending on its location in the body. The peritoneum is the mesothelial tissue that covers most of the organs in the abdominal cavity. The pleura is the membrane that surrounds the lungs and lines the wall of the chest cavity. The pericardium covers and protects the heart. The mesothelial tissue surrounding the male internal reproductive organs is called the tunica vaginalis testis. The tunica serosa uteri covers the internal reproductive organs in women.
What is mesothelioma?
Mesothelioma (cancer of the mesothelium) is a disease in which cells of the mesothelium become abnormal and divide without control or order. They can invade and damage nearby tissues and organs. Cancer cells can also metastasize (spread) from their original site to other parts of the body. Most cases of mesothelioma begin in the pleura or peritoneum.
A doctor should be seen if a person has shortness of breath, pain in the chest, or pain or swelling in the abdomen. If there are symptoms, the doctor may order an x-ray of the chest or abdomen.
The doctor may look inside the chest cavity with a special instrument called a thoracoscope. A cut will be made through the chest wall and the thoracoscope will be put into the chest between two ribs. This test, called thoracoscopy, is usually done in the hospital. Before the test, the patient will be given a local anesthetic (a drug that causes a loss of feeling for a short period of time). Some pressure may be felt, but usually there is no pain.
The doctor may also look inside the abdomen (peritoneoscopy) with a special tool called a peritoneoscope. The peritoneoscope is put into an opening made in the abdomen. This test is also usually done in the hospital. Before the test is done, a local anesthetic will be given.
If tissue that is not normal is found, the doctor will need to cut out a small piece and have it looked at under a microscope to see if there are any cancer cells. This is called a biopsy. Biopsies are usually done during the thoracoscopy or peritoneoscopy.
The chance of recovery (prognosis) depends on the size of the cancer, where the cancer is, how far the cancer has spread, how the cancer cells look under the microscope, how the cancer responds to treatment, and the patient's age.
The first step in any successful battle against mesothelioma is to become informed. Please visit our mesothelioma treatment options page to assist you in finding mesothelioma specialists or simply call us and we will be glad to discuss a variety of treatment options with you.
At Blumenthal and Gruber, LLP we pride ourselves in our personal and ongoing relationships with our clients and their families. Our clients page will allow you to hear from some of the people we have helped and learn more about the lawyers at our firm.
As attorneys who have dedicated their careers to fighting for the rights of industrial disease victims, our job is to hold the asbestos companies accountable for the harm they have caused.
Mesothelioma is a rare form of cancer in which malignant (cancerous) cells are found in the mesothelium, a protective sac that covers most of the body's internal organs. Most people who develop mesothelioma have worked on jobs where they inhaled asbestos particles.
What is the mesothelium?
The mesothelium is a membrane that covers and protects most of the internal organs of the body. It is composed of two layers of cells: One layer immediately surrounds the organ; the other forms a sac around it. The mesothelium produces a lubricating fluid that is released between these layers, allowing moving organs (such as the beating heart and the expanding and contracting lungs) to glide easily against adjacent structures.
The mesothelium has different names, depending on its location in the body. The peritoneum is the mesothelial tissue that covers most of the organs in the abdominal cavity. The pleura is the membrane that surrounds the lungs and lines the wall of the chest cavity. The pericardium covers and protects the heart. The mesothelial tissue surrounding the male internal reproductive organs is called the tunica vaginalis testis. The tunica serosa uteri covers the internal reproductive organs in women.
What is mesothelioma?
Mesothelioma (cancer of the mesothelium) is a disease in which cells of the mesothelium become abnormal and divide without control or order. They can invade and damage nearby tissues and organs. Cancer cells can also metastasize (spread) from their original site to other parts of the body. Most cases of mesothelioma begin in the pleura or peritoneum.
A doctor should be seen if a person has shortness of breath, pain in the chest, or pain or swelling in the abdomen. If there are symptoms, the doctor may order an x-ray of the chest or abdomen.
The doctor may look inside the chest cavity with a special instrument called a thoracoscope. A cut will be made through the chest wall and the thoracoscope will be put into the chest between two ribs. This test, called thoracoscopy, is usually done in the hospital. Before the test, the patient will be given a local anesthetic (a drug that causes a loss of feeling for a short period of time). Some pressure may be felt, but usually there is no pain.
The doctor may also look inside the abdomen (peritoneoscopy) with a special tool called a peritoneoscope. The peritoneoscope is put into an opening made in the abdomen. This test is also usually done in the hospital. Before the test is done, a local anesthetic will be given.
If tissue that is not normal is found, the doctor will need to cut out a small piece and have it looked at under a microscope to see if there are any cancer cells. This is called a biopsy. Biopsies are usually done during the thoracoscopy or peritoneoscopy.
The chance of recovery (prognosis) depends on the size of the cancer, where the cancer is, how far the cancer has spread, how the cancer cells look under the microscope, how the cancer responds to treatment, and the patient's age.
Malignant mesothelioma is a rare form of cancer in which the cancer (malignant) cells are found in the sac lining of the chest (the pleura), the lining of the abdominal cavity (the peritoneum) or the lining around the heart (the pericardium). It can also be single handedly pointed to the exposure of asbestos as the cause. Mesothelioma is a cancer that is particularly difficult for doctors to diagnose and one that usually does not respond well to therapy.
Mesothelioma’s Cause - Asbestos Exposure
At some point in our lives, nearly all of us are exposed to asbestos via the air we breathe and the water that we drink. This can be from natural deposits in the earth and from the deterioration of asbestos products around us. Most of us, however, will not become ill as a result of the exposure. Most people who develop mesothelioma have worked on jobs where they inhaled asbestos particles, or they have been exposed to asbestos dust and fiber in various ways. Washing the clothes of a family member who worked with asbestos can also put a person at risk for developing mesothelioma. Unlike lung cancer, there is no association between mesothelioma and smoking, but smoking greatly increases the risk of other asbestos induced cancer.
As early as the late 1800’s asbestos was used commercially in North America, but it’s use increased dramatically during the World War II era when shipyards produced massive numbers of ships for the war effort. Since then asbestos containing products were used by the construction, building, automotive and manufacturing industries. For more than 50 years, products containing asbestos remained unregulated, and the manufacturer of those products continued to produce, knowing full well that many of the millions of workers who came into contact with their products would ultimately suffer from it’s exposure. Finally, in the late 1970s, the Consumer Products Safety Commission banned the use of asbestos in wallboard patching compounds and artificial ash for gas fireplaces because the fiber could easily be released during it’s use. Then in 1989, the Environmental Protection Agency banned all new use of asbestos, but uses established prior to that time were still allowed. Although awareness of the dangers of asbestos and public concern over the issue have led to a decline in domestic consumption over the years, a total ban on asbestos has not come to completion. Asbestos are still being imported, used and are still dangerous to the very people that are exposed to it.
Types of Mesothelioma
Pleural MesotheliomaPleural disease is often seen in people who have been exposed to high levels of asbestos while on the job. It usually takes 10 years or more for changes to appear that are indicative of pleural disease which affects the thin membrane layer in the chest. These differences can include a thickening or calcification of the pleural lining and is usually diagnosed as pleural plaques, pleural thickening and pleural calcification.In most cases, pleural disease is not considered fatal but it does have the ability to impair the lung function and the individual could be at a higher risk of developing more severe asbestos cancer.
Pericardial MesotheliomaMalignant pericardial mesothelioma is a type of cancer that originates in the mesothelium, a thin wall of cells that surround the body’s organs and internal body structures. Pericardial mesothelioma originates in the lining of the heart. Pericardial mesothelioma is known to be caused by exposure to asbestos. While the precise route by which microscopic asbestos fibers reaches the pericardial lining is not known, physicians surmise that inhaled asbestos fibers are absorbed into the bloodstream and become entangled in the heart’s lining as the blood processes through the heart. Mesothelioma occurring in other parts of the body, such as in the pleura or peritoneum, can also metastasize to the pericardial lining. Pericardial mesothelioma is the rarest of these malignancies and accounts for only an estimated 10% of all mesothelioma incidences annually.
Peritoneal MesotheliomaMalignant peritoneal mesothelioma is a rare type of cancer that occurs in the thin cell walls which surround the abdominal cavity, known as the peritoneum. Peritoneal mesothelioma is the second rarest form of the disease and accounts for approximately 20% of all mesothelioma cases each year. Peritoneal mesothelioma is known only to be caused by exposure to asbestos said to reach the abdominal wall by one of two methods. The first is through ingested asbestos fibers which are processed through digestion and become lodged in peritoneum. These other method is through the lungs and lymph nodes, by inhaled asbestos fibers.
Mesothelioma’s Cause - Asbestos Exposure
At some point in our lives, nearly all of us are exposed to asbestos via the air we breathe and the water that we drink. This can be from natural deposits in the earth and from the deterioration of asbestos products around us. Most of us, however, will not become ill as a result of the exposure. Most people who develop mesothelioma have worked on jobs where they inhaled asbestos particles, or they have been exposed to asbestos dust and fiber in various ways. Washing the clothes of a family member who worked with asbestos can also put a person at risk for developing mesothelioma. Unlike lung cancer, there is no association between mesothelioma and smoking, but smoking greatly increases the risk of other asbestos induced cancer.
As early as the late 1800’s asbestos was used commercially in North America, but it’s use increased dramatically during the World War II era when shipyards produced massive numbers of ships for the war effort. Since then asbestos containing products were used by the construction, building, automotive and manufacturing industries. For more than 50 years, products containing asbestos remained unregulated, and the manufacturer of those products continued to produce, knowing full well that many of the millions of workers who came into contact with their products would ultimately suffer from it’s exposure. Finally, in the late 1970s, the Consumer Products Safety Commission banned the use of asbestos in wallboard patching compounds and artificial ash for gas fireplaces because the fiber could easily be released during it’s use. Then in 1989, the Environmental Protection Agency banned all new use of asbestos, but uses established prior to that time were still allowed. Although awareness of the dangers of asbestos and public concern over the issue have led to a decline in domestic consumption over the years, a total ban on asbestos has not come to completion. Asbestos are still being imported, used and are still dangerous to the very people that are exposed to it.
Types of Mesothelioma
Pleural MesotheliomaPleural disease is often seen in people who have been exposed to high levels of asbestos while on the job. It usually takes 10 years or more for changes to appear that are indicative of pleural disease which affects the thin membrane layer in the chest. These differences can include a thickening or calcification of the pleural lining and is usually diagnosed as pleural plaques, pleural thickening and pleural calcification.In most cases, pleural disease is not considered fatal but it does have the ability to impair the lung function and the individual could be at a higher risk of developing more severe asbestos cancer.
Pericardial MesotheliomaMalignant pericardial mesothelioma is a type of cancer that originates in the mesothelium, a thin wall of cells that surround the body’s organs and internal body structures. Pericardial mesothelioma originates in the lining of the heart. Pericardial mesothelioma is known to be caused by exposure to asbestos. While the precise route by which microscopic asbestos fibers reaches the pericardial lining is not known, physicians surmise that inhaled asbestos fibers are absorbed into the bloodstream and become entangled in the heart’s lining as the blood processes through the heart. Mesothelioma occurring in other parts of the body, such as in the pleura or peritoneum, can also metastasize to the pericardial lining. Pericardial mesothelioma is the rarest of these malignancies and accounts for only an estimated 10% of all mesothelioma incidences annually.
Peritoneal MesotheliomaMalignant peritoneal mesothelioma is a rare type of cancer that occurs in the thin cell walls which surround the abdominal cavity, known as the peritoneum. Peritoneal mesothelioma is the second rarest form of the disease and accounts for approximately 20% of all mesothelioma cases each year. Peritoneal mesothelioma is known only to be caused by exposure to asbestos said to reach the abdominal wall by one of two methods. The first is through ingested asbestos fibers which are processed through digestion and become lodged in peritoneum. These other method is through the lungs and lymph nodes, by inhaled asbestos fibers.
Tuesday, June 9, 2009
Mesothelioma Treatment
Treatment options for mesothelioma include surgery, radiation therapy, chemotherapy, and a combination of these methods. The treatment recommended by the healthcare provider will depend on factors such as the stage of the cancer, the type of cancer cells, and the person's general health. Treatment for mesothelioma generally begins a few weeks after diagnosis, so there often is time to get a second opinion.
There are several different mesothelioma treatment options available for someone diagnosed with the disease.
Some factors that may influence the treatment options recommended include:
- The stage of the cancer (see Mesothelioma Stages)
- The type of cancer cells (how they look under a microscope)
- The person's age and general health
- Whether the mesothelioma is newly diagnosed or has come back (recurred).
In general, treatment options for mesothelioma include:
- Surgery (see Mesothelioma Surgery)
- Chemotherapy (see Mesothelioma Chemotherapy)
- Radiation therapy (see Mesothelioma Radiation).
Your doctor can describe your treatment choices and the expected results of each. The two of you can work together to develop a treatment plan that meets your medical needs and personal values. Choosing the most appropriate treatment is a decision that ideally involves the patient, family, and healthcare team.
Mesothelioma treatment generally begins within a few weeks after the diagnosis. There will be time for people to talk with their healthcare provider about treatment choices, get a second opinion, and learn more about the disease.
There are several different mesothelioma treatment options available for someone diagnosed with the disease.
Some factors that may influence the treatment options recommended include:
- The stage of the cancer (see Mesothelioma Stages)
- The type of cancer cells (how they look under a microscope)
- The person's age and general health
- Whether the mesothelioma is newly diagnosed or has come back (recurred).
In general, treatment options for mesothelioma include:
- Surgery (see Mesothelioma Surgery)
- Chemotherapy (see Mesothelioma Chemotherapy)
- Radiation therapy (see Mesothelioma Radiation).
Your doctor can describe your treatment choices and the expected results of each. The two of you can work together to develop a treatment plan that meets your medical needs and personal values. Choosing the most appropriate treatment is a decision that ideally involves the patient, family, and healthcare team.
Mesothelioma treatment generally begins within a few weeks after the diagnosis. There will be time for people to talk with their healthcare provider about treatment choices, get a second opinion, and learn more about the disease.
Remembering Questions and Answers
Many people with mesothelioma want to take an active part in making decisions about their medical care. They want to learn all they can about the disease and their treatment choices. However, the shock and stress after a mesothelioma diagnosis can make it hard to think of everything to ask the doctor. Often, it helps to make a list of questions before an appointment.
To help remember what the doctor says, people may take notes or ask whether they may use a tape recorder. Some also want to have a family member or friend with them when they talk to the doctor -- to take part in the discussion, to take notes, or just to listen.
Sometimes it is helpful to have a second opinion about the diagnosis and the treatment plan. Some insurance companies require a second opinion; others may cover a second opinion if the affected person or doctor requests it. Gathering medical records and arranging to see another doctor may take a little time. In most cases, a brief delay to get another opinion will not affect treatment for mesothelioma.
The doctor is the best person to describe the treatment choices and explain the expected results. The doctor and the affected person can work together to develop a mesothelioma treatment plan that fits the person needs.
Depending on the type and extent of mesothelioma, options may include:
- Surgery
- Chemotherapy
- Radiation therapy
- A combination of these methods.
(You can read more about treatment options based on the stage of mesothelioma by going to the eMedTV article Mesothelioma Treatment by Stage.)
Side Effects of Treatment for Mesothelioma
Because treatment for mesothelioma may damage healthy cells and tissues, unwanted side effects are common. Specific side effects depend on many factors, including the type and extent of the treatment. Side effects may not be the same for each person, and they may even change from one treatment session to the next. Before treating mesothelioma, healthcare providers will explain possible side effects and suggest ways to manage them.
People need to eat well during mesothelioma treatment. They need enough calories to maintain a good weight and protein to keep up strength. Good "mesothelioma nutrition" often helps people with cancer feel better and have more energy.
But eating well can be difficult. People may not feel like eating if they are uncomfortable or tired. Also, the side effects of treatment, such as poor appetite, nausea, or vomiting, can be a problem. Foods may taste different. Nevertheless, people should try to eat enough calories and protein to control weight loss, maintain strength, and promote healing. Also, eating well often helps people with cancer feel better and have more energy. The doctor, dietitian, or other healthcare provider can suggest ways to maintain a healthy diet.
Careful planning and checkups are important. Mesothelioma and its treatment may make it hard for people to digest food and maintain their weight. The doctor will check the person for weight loss, weakness, and lack of energy.
Mesothelioma can be hard to control with current treatments. For that reason, many doctors encourage people with mesothelioma to consider taking part in a clinical trial. These mesothelioma research trials are meant to help improve current treatments or obtain information on new treatments for mesothelioma. When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment. Clinical trials are an important option for people with all stages of mesothelioma.
ll explain possible side effects and suggest ways to manage them.
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